50118

(4S)-4-Hydroxy-L-isoleucine

≥98.0% (TLC)

• Synonyme(s) : 4-HYDROXYISOLEUCINE, HIL, (2S,3R,4S)-2-Amino-4-hydroxy-3-methylpentanoic acid
• Formule empirique (notation de Hill) : C₆H₁₃NO₃
• CAS Number: 55399-93-4
• Poids moléculaire : 147.17
• Beilstein: 4128096
• Numéro MDL: MFCD07357252
• Code UNSPSC : 12352209
• eCl@ss : 32160406
• ID de substance PubChem : 329757568
• Nomenclature NACRES : NA.26

Propriétés

• Product Name: (4S)-4-Hydroxy-L-isoleucine, from fenugreek seeds, ≥98.0% (TLC)
• Source biologique: fenugreek seeds
• Niveau de qualité: 100
• Essai: ≥98.0% (TLC)
• Forme: powder or flakes
• Activité optique: [α]/D +32.5±2.0°, c = 1 in H₂O
• Couleur: white to almost white
• Température de stockage: 2-8°C
• Chaîne SMILES: C[C@H](O)[C@H](C)[C@H](N)C(O)=O
• InChI: 1S/C6H13NO3/c1-3(4(2)8)5(7)6(9)10/h3-5,8H,7H2,1-2H3,(H,9,10)/t3-,4-,5-/m0/s1
• Clé InChI: OSCCDBFHNMXNME-YUPRTTJUSA-N

Description

Actions biochimiques/physiologiques

(4S)-4-Hydroxy-L-isoleucine (HIL) is a non-proteinogenic α amino acid produced by the activity of bacterial isoleucine dioxygenase(s). (2S,3R,4S)-HIL is being studied to understand its insulinotropic (anti-diabetic) and anti-obesity effects.

4-Hydroxyisoleucine (HIL) from fenugreek (Trigonella foenum-graecum) seeds is a potential insulinotropic (anti-diabetic) and anti-obesity amino acid. HIL stimulates glucose-dependent insulin secretion from pancreatic cells. HIL activates insulin receptor substrate-associated phosphoinositide 3 (PI3) kinase activity. HIL reduces plasma levels of triglycerides, free fatty acids and cholesterol.

Conditionnement

Bottomless glass bottle. Contents are inside inserted fused cone.

Informations sur la sécurité

• Pictogrammes: GHS07
• Mention d'avertissement: Warning
• Mentions de danger: H315,H319,H335
• Conseils de prudence: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Classification des risques: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Organes cibles: Respiratory system
• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): 296.6 °F
• Point d'éclair (°C): 147 °C
• Équipement de protection individuelle: dust mask type N95 (US), Eyeshields, Gloves