85580

Spermidine trihydrochloride

≥99.0% (AT)

• Synonyme(s) : N-(3-Aminopropyl)-1,4-butanediamine trihydrochloride
• Formule linéaire : NH₂(CH₂)₃NH(CH₂)₄NH₂ · 3HCl
• CAS Number: 334-50-9
• Poids moléculaire : 254.63
• Beilstein: 3552356
• Numéro CE : 206-379-0
• Numéro MDL: MFCD00012918
• Code UNSPSC : 12352204
• ID de substance PubChem : 329769390
• Nomenclature NACRES : NA.77

Propriétés

• Source biologique: microbial; synthetic
• Niveau de qualité: 200
• Essai: ≥99.0% (AT)
• Forme: powder
• Pf: ~250 °C (dec.); 257-259 °C (lit.)
• Solubilité: H₂O: 0.1 g/mL, clear, colorless
• Température de stockage: room temp
• Chaîne SMILES: Cl[H].Cl[H].Cl[H].NCCCCNCCCN
• InChI: 1S/C7H19N3.3ClH/c8-4-1-2-6-10-7-3-5-9;;;/h10H,1-9H2;3*1H
• Clé InChI: LCNBIHVSOPXFMR-UHFFFAOYSA-N

Description

Description générale

Spermidine is a polyamine and a trivalent organic cation.

Application

Spermidine trihydrochloride has been used as standard for the detection of biogenic amines using HPLC.

Actions biochimiques/physiologiques

Inhibits neuronal nitric oxide synthase (nNOS). Binds and precipitates DNA; Stimulates T₄ polynucleotide kinase activity.

Inhibits neuronal nitric oxide synthase (nNOS). Binds and precipitates DNA; may be used for purification of DNA binding proteins. Stimulates T₄ polynucleotide kinase activity.

Spermidine modulates various cellular activities like cellular development and differentiation, stability of DNA and apoptosis.

Attention

Solutions should be sterile-filtered, not autoclaved, if sterile solution is necessary. Spermidine deaminates with time; solutions should be stored frozen. Prepare new solutions frequently.

Informations sur la sécurité

• Pictogrammes: GHS07
• Mention d'avertissement: Warning
• Mentions de danger: H315,H319
• Conseils de prudence: P264 - P280 - P302 + P352 - P305 + P351 + P338 - P332 + P313 - P337 + P313
• Classification des risques: Eye Irrit. 2 - Skin Irrit. 2
• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: dust mask type N95 (US), Eyeshields, Gloves