S1141

Spermine tetrahydrochloride

BioReagent

• Synonyme(s) : N,N′-Bis(3-aminopropyl)-1,4-butanediamine tetrahydrochloride
• Formule empirique (notation de Hill) : C₁₀H₂₆N₄ · 4HCl
• CAS Number: 306-67-2
• Poids moléculaire : 348.18
• Beilstein: 3911771
• Numéro CE : 206-189-8
• Numéro MDL: MFCD00012914
• Code UNSPSC : 12352116
• ID de substance PubChem : 24899462
• Nomenclature NACRES : NA.52

Propriétés

• Qualité: Molecular Biology
• Niveau de qualité: 300
• Gamme de produits: BioReagent
• Forme: solid
• Pf: 310-311 °C (dec.) (lit.)
• Solubilité: H₂O: soluble 100 mg/mL, clear, colorless to light yellow
• Activité étrangère: DNase, RNase, protease, NICKase, none detected
• Température de stockage: room temp
• Chaîne SMILES: Cl.Cl.Cl.Cl.NCCCNCCCCNCCCN
• InChI: 1S/C10H26N4.4ClH/c11-5-3-9-13-7-1-2-8-14-10-4-6-12;;;;/h13-14H,1-12H2;4*1H
• Clé InChI: XLDKUDAXZWHPFH-UHFFFAOYSA-N

Description

Description générale

Spermine is a polyamine involved in cellular metabolism and DNA stabilization. In molecular biology it can be used in buffers for purification of DNA.

Application

Used to precipitate DNA from low salt aqueous buffers.

Actions biochimiques/physiologiques

Mixed NMDA agonist/antagonist at the polyamine site. Neuroprotective effects have been observed at high concentrations (1 mM), while neurotoxicity is observed at lower concentrations. It enhances agonist effectiveness at the strychnine-insensitive glycine site. Plays a role in cellular proliferation and differentiation; inhibits neuronal nitric oxide synthase (nNOS).

Mixed NMDA agonist/antagonist at the polyamine site. Plays a role in cellular proliferation and differentiation; inhibits neuronal nitric oxide synthase (nNOS).

Mixed NMDA agonist/antagonist at the polyamine site. Role in cellular proliferation and differentiation; inhibits neuronal nitric oxide synthase (nNOS).

Informations sur la sécurité

• Pictogrammes: GHS07
• Mention d'avertissement: Warning
• Mentions de danger: H315,H319
• Conseils de prudence: P264 - P280 - P302 + P352 - P305 + P351 + P338 - P332 + P313 - P337 + P313
• Classification des risques: Eye Irrit. 2 - Skin Irrit. 2
• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: dust mask type N95 (US), Eyeshields, Gloves