85590

Spermine

≥99.0% (GC)

• Synonyme(s) : N,N′-Bis(3-aminopropyl)-1,4-diaminobutane, Gerontine, Musculamine, Neuridine
• Formule linéaire : NH₂(CH₂)₃NH(CH₂)₄NH(CH₂)₃NH₂
• CAS Number: 71-44-3
• Poids moléculaire : 202.34
• Beilstein: 1750791
• Numéro CE : 200-754-2
• Numéro MDL: MFCD00008215
• Code UNSPSC : 12352116
• ID de substance PubChem : 329769392
• Nomenclature NACRES : NA.25

Propriétés

• Source biologique: microbial; synthetic
• Niveau de qualité: 200
• Essai: ≥99.0% (GC)
• Forme: crystalline (chunks)
• Impuretés: ≤0.5% spermidine
• pb: 150 °C/5 mmHg (lit.)
• Pf: 28-30 (lit.)
• Solubilité: water: 0.05 g/mL, clear, colorless
• Traces d'anions: carbonate (CO₃^2-): ≤5000 mg/kg
• Température de stockage: 2-8°C
• Chaîne SMILES: [H]N(CCCN)CCCCN([H])CCCN
• InChI: 1S/C10H26N4/c11-5-3-9-13-7-1-2-8-14-10-4-6-12/h13-14H,1-12H2
• Clé InChI: PFNFFQXMRSDOHW-UHFFFAOYSA-N

Description

Application

Spermine, a polycationic biogenic polyamine derived from spermidine, may be used in a wide variety of biological applications as a supplement or regulatory agent.Used as co-matrix with DHB for MALDI-MS of sialylated glycans in negative ion mode.

Actions biochimiques/physiologiques

Mixed NMDA agonist/antagonist at the polyamine site. Plays a role in cellular proliferation and differentiation; inhibits neuronal nitric oxide synthase (nNOS).

Mixed NMDA glutamate receptor agonist/antagonist at the polyamine site. Neuroprotective effects have been observed at high concentrations (1 mM), while neurotoxicity is observed at lower concentrations. It enhances agonist effectiveness at the strychnine-insensitive glycine site. Plays a role in cellular proliferation and differentiation; inhibits neuronal nitric oxide synthase (nNOS).

Informations sur la sécurité

• Pictogrammes: GHS05
• Mention d'avertissement: Danger
• Mentions de danger: H314
• Conseils de prudence: P260 - P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338 - P363
• Classification des risques: Eye Dam. 1 - Skin Corr. 1B
• Code de la classe de stockage: 8A - Combustible corrosive hazardous materials
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges