A4377

S-(5′-Adenosyl)-L-methionine iodide

≥80% (spectrophotometric assay), suitable for cell culture

• Synonyme(s) : AdoMet, SAM
• Formule empirique (notation de Hill) : C₁₅H₂₃IN₆O₅S
• CAS Number: 3493-13-8
• Poids moléculaire : 526.35
• Beilstein: 4120787
• Numéro CE : 222-486-5
• Numéro MDL: MFCD00043192
• Code UNSPSC : 12352209
• ID de substance PubChem : 24890852
• Nomenclature NACRES : NA.26

Propriétés

• Product Name: S-(5′-Adenosyl)-L-methionine iodide, ≥80% (HPLC), ≥80% (spectrophotometric assay)
• Niveau de qualité: 200
• Essai: ≥80% (HPLC); ≥80% (spectrophotometric assay)
• Forme: powder
• Technique(s): cell culture | mammalian: suitable
• Couleur: white to off-white
• Solubilité: H₂O: 100 mg/mL
• Conditions d'expédition: dry ice
• Température de stockage: −20°C
• Chaîne SMILES: [I-].C[S+](CC[C@H](N)C(O)=O)C[C@H]1O[C@H]([C@H](O)[C@@H]1O)n2cnc3c(N)ncnc23
• InChI: 1S/C15H22N6O5S.HI/c1-27(3-2-7(16)15(24)25)4-8-10(22)11(23)14(26-8)21-6-20-9-12(17)18-5-19-13(9)21;/h5-8,10-11,14,22-23H,2-4,16H2,1H3,(H2-,17,18,19,24,25);1H/t7-,8+,10+,11+,14+,27?;/m0./s1
• Clé InChI: XQMWYLXPEGFCFT-XKGORWRGSA-N

Description

Application

S-(5′-Adenosyl)-L-methionine (SAM, AdoMet) is used as a primary methyl donor molecule in mammalian cell culture and the first step metabolite in methionine biosynthesis.

Actions biochimiques/physiologiques

Methyl donor; cofactor for enzyme-catalyzed methylations, including catechol O-methyltransferase (COMT) and DNA methyltransferases (DNMT). Although present in all cells, it is concentrated in liver where 85% of all methylation reactions occur. It is also involved in regulating liver function, growth, and response to injury.

Attention

This material is very unstable at room temperature.

Remarque sur l'analyse

Purity based on UV and HPLC.

Informations sur la sécurité

• Pictogrammes: GHS07
• Mention d'avertissement: Warning
• Mentions de danger: H317
• Conseils de prudence: P261 - P272 - P280 - P302 + P352 - P333 + P313 - P362 + P364
• Classification des risques: Skin Sens. 1
• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Faceshields, Gloves, type N95 (US)