A8106

Altanserin hydrochloride hydrate

≥98% (HPLC), solid

• Synonyme(s) : 3-[2-[4-(4-Fluorobenzoyl)-1-piperidinyl]ethyl]-2,3-dihydro-2-thioxo-4(1H)-quinazolinone hydrochloride hydrate
• Formule empirique (notation de Hill) : C₂₂H₂₂FN₃O₂S · HCl · xH₂O
• CAS Number: 76330-71-7
• Poids moléculaire : 447.95 (anhydrous basis)
• Numéro MDL: MFCD11045280
• Code UNSPSC : 12352200
• ID de substance PubChem : 329770947
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Essai: ≥98% (HPLC)
• Forme: solid
• Solubilité: DMSO: >5 mg/mL; H₂O: insoluble
• Température de stockage: 2-8°C
• Chaîne SMILES: O.Cl.Fc1ccc(cc1)C(=O)C2CCN(CC2)CCN3C(=S)Nc4ccccc4C3=O
• InChI: 1S/C22H22FN3O2S.ClH.H2O/c23-17-7-5-15(6-8-17)20(27)16-9-11-25(12-10-16)13-14-26-21(28)18-3-1-2-4-19(18)24-22(26)29;;/h1-8,16H,9-14H2,(H,24,29);1H;1H2
• Clé InChI: MFGBKMPKRJCLPK-UHFFFAOYSA-N

Description

Application

Altanserin hydrochloride hydrate has been used in the pretreatment of rat brain samples and as a non-radioactive control in the calibration curve preparation for quantifying ^[18F]altanserin in high-performance liquid chromatography.

Altanserin hydrochloride hydrate is a specific 5-HT₂/serotonergic antagonist and has been used in a study to assess serotonin release capacity in the human brain.

Actions biochimiques/physiologiques

Altanserin hydrochloride hydrate is a specific 5-HT₂/serotonergic antagonist.

The radioligand of altanserin, ^[18F]altanserin is useful as a positron emission tomography (PET)-radioligand for the visualization and quantification of serotonin_2A (5-HT_2A) receptors.

Informations sur la sécurité

• Pictogrammes: GHS07
• Mention d'avertissement: Warning
• Mentions de danger: H319
• Conseils de prudence: P264 - P280 - P305 + P351 + P338 - P337 + P313
• Classification des risques: Eye Irrit. 2
• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: dust mask type N95 (US), Eyeshields, Gloves