C2389

Cerulenin

from Cephalosporium caerulens, ≥98% (HPLC), powder, de novo phospholipid synthesis inhibitor

• Synonyme(s) : Helicocerin, (2R,3S,E,E)-2,3-Epoxy-4-oxo-7,10-dodecadienamide
• Formule empirique (notation de Hill) : C₁₂H₁₇NO₃
• CAS Number: 17397-89-6
• Poids moléculaire : 223.27
• Beilstein: 4140423
• Numéro CE : 241-424-8
• Numéro MDL: MFCD00083595
• Code UNSPSC : 51111800
• ID de substance PubChem : 24892323
• Nomenclature NACRES : NA.77

Propriétés

• Product Name: Cerulenin, ≥98% (HPLC), from Cephalosporium caerulens
• Source biologique: Cephalosporium caerulens
• Niveau de qualité: 200
• Essai: ≥98% (HPLC)
• Forme: powder
• Pf: 93 °C
• Solubilité: acetone: 19.60-20.40 mg/mL, clear to slightly hazy, colorless to yellow
• Spectre d'activité de l'antibiotique: fungi
• Mode d’action: enzyme | inhibits
• Température de stockage: −20°C
• Chaîne SMILES: C/C=C/C/C=C/CCC([C@@H]1[C@H](C(N)=O)O1)=O
• InChI: 1S/C13H18O3/c1-3-4-5-6-7-8-9-11(15)13-12(16-13)10(2)14/h3-4,6-7,12-13H,5,8-9H2,1-2H3/b4-3+,7-6+/t12-,13+/m0/s1
• Clé InChI: PTNNGEBMCNMENY-JIVMHGEESA-N
• Informations sur le gène: human ... FASN(2194)

Description

Description générale

Cerulenin, an inhibitor of de novo phospholipid synthesis triggers apoptosis in various wild type p53 and mutant p53 tumor cell lines. This fungal antibiotic also blocks the condensing enzyme involved in fatty acid and polyketide biosynthesis.

Application

Cerulenin has been used:

• as a fatty acid synthase inhibitor to study its effects on aldosterone-induced trained immunity
• as a blocker of fatty acid synthase to study its effects on the replication of severe acute respiratory syndrome coronavirus 2 (SARS-CoV2)
• as a supplement in yeast extract–peptone–dextrose/glycerol (YPD/G) agar plates for the isolation of cerulenin-resistant yeast strains

Informations sur la sécurité

• Pictogrammes: GHS07
• Mention d'avertissement: Warning
• Mentions de danger: H302
• Classification des risques: Acute Tox. 4 Oral
• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: dust mask type N95 (US), Eyeshields, Gloves