C5490

C75

≥98% (HPLC), powder

• Synonyme(s) : 4-Methylene-2-octyl-5-oxotetrahydrofuran-3-carboxylic acid
• Formule empirique (notation de Hill) : C₁₄H₂₂O₄
• CAS Number: 218137-86-1
• Poids moléculaire : 254.32
• Numéro MDL: MFCD03426157
• Code UNSPSC : 41121801
• ID de substance PubChem : 24892789
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Essai: ≥98% (HPLC)
• Forme: powder
• Couleur: white to beige
• Solubilité: DMSO: 5 mg/mL, clear
• Température de stockage: 2-8°C
• Chaîne SMILES: CCCCCCCCC1OC(=O)C(=C)C1C(O)=O
• InChI: 1S/C14H22O4/c1-3-4-5-6-7-8-9-11-12(13(15)16)10(2)14(17)18-11/h11-12H,2-9H2,1H3,(H,15,16)
• Clé InChI: VCWLZDVWHQVAJU-UHFFFAOYSA-N

Description

Application

C75 has been used:

• as a fatty acid synthase (FASN) inhibitor to test its ability in the direct inhibition of FASN to attenuate mammosphere formation as compared to metformin
• as a pharmacological inhibitor to inhibit fatty acid synthesis in glioma stem cells (GSCs)
• as FAS inhibitor in the pre-treatment of Chang cells to inhibit lipogenesis and reverse the senescence induced by hydrogen peroxide

Actions biochimiques/physiologiques

C75 helps to increase the cancer‐killing capability of ionizing radiation.

C75 is a novel, potent synthetic inhibitor of fatty acid synthase (FAS), which is used as a tool for studying fatty acid synthesis in metabolic disorders and cancer.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Gloves, type N95 (US)