C7971

Cilostamide

phosphodiesterase inhibitor

• Synonyme(s) : 6-[3-(N-Cyclohexyl-N-methylcarbamoyl)propoxy]quinolin-2[1H]-one, OPC 3689
• Formule empirique (notation de Hill) : C₂₀H₂₆N₂O₃
• CAS Number: 68550-75-4
• Poids moléculaire : 342.43
• Numéro MDL: MFCD00673958
• Code UNSPSC : 12352202
• ID de substance PubChem : 24278337
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Essai: ≥97% (HPLC)
• Forme: powder
• Solubilité: DMSO: 20 mg/mL, clear, colorless to faintly yellow
• Chaîne SMILES: CN(C1CCCCC1)C(=O)CCCOc2ccc3NC(=O)C=Cc3c2
• InChI: 1S/C20H26N2O3/c1-22(16-6-3-2-4-7-16)20(24)8-5-13-25-17-10-11-18-15(14-17)9-12-19(23)21-18/h9-12,14,16H,2-8,13H2,1H3,(H,21,23)
• Clé InChI: UIAYVIIHMORPSJ-UHFFFAOYSA-N
• Informations sur le gène: human ... PDE3A(5139), PDE3B(5140), PDE5A(8654), PDE7A(5150) ; rat ... Pde2a(81743), Pde4a(25638)

Description

Actions biochimiques/physiologiques

PDE3 catalyzes the phosphodiester bond hydrolysis, observed in secondory messengers such as cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP). Inhibitors of PDE3 are generally inotropic and vasodilatory. They are being recognized for its use in treating heart failures. Cilostamide is known to delay meiotic progression.

Selective cGMP-inhibited phosphodiesterase inhibitor (PDE3); IC₅₀ = 70 ± 9 nM.

Selective inhibitor of PDE3 (cGMP-inhibited phosphodiesterase); IC₅₀ = 70 ± 9 nM. This inhibitory effect increases intracellular cAMP and inhibits platelet aggregation.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Gloves, type N95 (US)