E4876

17α-Ethynylestradiol

≥98%

• Synonyme(s) : Ethinylestradiol
• Formule empirique (notation de Hill) : C₂₀H₂₄O₂
• CAS Number: 57-63-6
• Poids moléculaire : 296.40
• Beilstein: 2419975
• Numéro CE : 200-342-2
• Numéro MDL: MFCD00003690
• Code UNSPSC : 12352200
• ID de substance PubChem : 24894585
• Nomenclature NACRES : NA.77

Propriétés

• Source biologique: synthetic
• Stérilité: non-sterile
• Essai: ≥98%
• Forme: powder
• Pf: 182-183 °C (lit.)
• Solubilité: ethanol: 50 mg/mL, clear, colorless to faintly yellow
• Conditions d'expédition: ambient
• Température de stockage: room temp
• Chaîne SMILES: [H][C@]12CC[C@@]3(C)[C@@]([H])(CC[C@@]3(O)C#C)[C@]1([H])CCc4cc(O)ccc24
• InChI: 1S/C20H24O2/c1-3-20(22)11-9-18-17-6-4-13-12-14(21)5-7-15(13)16(17)8-10-19(18,20)2/h1,5,7,12,16-18,21-22H,4,6,8-11H2,2H3/t16-,17-,18+,19+,20+/m1/s1
• Clé InChI: BFPYWIDHMRZLRN-SLHNCBLASA-N
• Informations sur le gène: human ... ESR1(2099) ; rat ... Afp(24177), Esr1(24890), Shbg(24775)

Description

Description générale

17α-Ethynylestradiol (EE2) is a synthetic hormone. It is a derivative of estradiol (E2). It is implicated in estrogen replacement therapy and suspension of breastfeeding. EE2 is used to treat osteoporosis, menopausal and postmenopausal syndrome. It is also used to treat prostatic cancer and breast cancer in postmenopausal women. EE2 functions as an endocrine-disrupting chemical (EDC).

Application

17α-Ethynylestradiol has been used to study the effect of exogenous estrogen and selective estrogen receptor modulator (SERM) in rats. It also has been used to increase the concentration of low density lipoprotein (LDL) receptor in rabbit liver.

Actions biochimiques/physiologiques

17α-Ethynylestradiol is an orally bio-active synthetic estrogen used as an oral contraceptive.

Informations sur la sécurité

• Pictogrammes: GHS08,GHS07,GHS09
• Mention d'avertissement: Danger
• Mentions de danger: H302,H351,H360Fd,H410
• Conseils de prudence: P202 - P264 - P273 - P280 - P301 + P312 - P308 + P313
• Classification des risques: Acute Tox. 4 Oral - Aquatic Chronic 1 - Carc. 2 - Repr. 1A
• Code de la classe de stockage: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Classe de danger pour l'eau (WGK): WGK 3
• Équipement de protection individuelle: Eyeshields, Gloves, type P3 (EN 143) respirator cartridges