G0500

D-(+)-Galactosamine hydrochloride

≥99% (HPLC)

• Synonyme(s) : 2-Amino-2-deoxy-D-galactopyranose hydrochloride, D-Chondrosamine hydrochloride
• Formule empirique (notation de Hill) : C₆H₁₃NO₅ · HCl
• CAS Number: 1772-03-8
• Poids moléculaire : 215.63
• Beilstein: 3697825
• Numéro CE : 217-198-1
• Numéro MDL: MFCD00135830
• Code UNSPSC : 12352201
• ID de substance PubChem : 24894912
• Nomenclature NACRES : NA.25

Propriétés

• Essai: ≥99% (HPLC)
• Forme: powder
• Technique(s): HPLC: suitable
• Impuretés: ≤0.5% Glucosamine (HPAE)
• Couleur: white to off-white
• Pf: 172-180 °C
• Solubilité: H₂O: 50 mg/mL, clear to slightly hazy, colorless to very faintly yellow
• Température de stockage: room temp
• Chaîne SMILES: Cl.N[C@@H](C=O)[C@@H](O)[C@@H](O)[C@H](O)CO
• InChI: 1S/C6H13NO5.ClH/c7-3(1-8)5(11)6(12)4(10)2-9;/h1,3-6,9-12H,2,7H2;1H/t3-,4+,5+,6-;/m0./s1
• Clé InChI: CBOJBBMQJBVCMW-NQZVPSPJSA-N

Description

Description générale

D-galactosamine (d-GalN) is a specific hepatotoxic agent metabolized particularly in hepatocytes. It is a 6-carbon amino sugar derived from galactose.

Application

D-(+)-Galactosamine (D-chondrosamine) has been used with lipopolysaccharides (LPS) to induce models of acute hepatic failure (LPS/D-GalN-induced liver injury, hepatitis) for therapeutic research to find new drugs.

D-(+)-Galactosamine hydrochloride has been used:

• for the surface binding of mannan-binding lectin (MBL) to modified mica surfaces
• in sterile phosphate buffer saline (PBS) before the intraperitoneal injection
• in mice for the generation of primary bone marrow-derived macrophages (BMDMs)

Actions biochimiques/physiologiques

Galactosamine (Gal) induces hepatocyte death both by necrosis and apoptosis. It prevents the production of liver RNA via the production of uridine diphosphate hexosamines. D-galactosamine lowers the intracellular pool of uracil nucleotides and thereby prevents the production of RNA and proteins.

Autres remarques

To gain a comprehensive understanding of our extensive range of Monosaccharides for your research, we encourage you to visit our Carbohydrates Category page.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Gloves, type N95 (US)