G7504

Guanosine 3′,5′-cyclic monophosphate

≥98% (HPLC), powder, intracellular mediator

• Synonyme(s) : cGMP, cyclic GMP
• Formule empirique (notation de Hill) : C₁₀H₁₂N₅O₇P
• CAS Number: 7665-99-8
• Poids moléculaire : 345.21
• Numéro CE : 231-641-6
• Numéro MDL: MFCD00070129
• Code UNSPSC : 41106305
• ID de substance PubChem : 24895309
• Nomenclature NACRES : NA.77

Propriétés

• Product Name: Guanosine 3′,5′-cyclic monophosphate, ≥98% (HPLC), powder
• Niveau de qualité: 200
• Essai: ≥98% (HPLC)
• Forme: powder
• Couleur: white
• Solubilité: 0.2 M NaHCO₃: 50 mg/mL
• Température de stockage: −20°C
• Chaîne SMILES: NC1=NC(=O)c2ncn(C3OC4COP(O)(=O)OC4C3O)c2N1
• InChI: 1S/C10H12N5O7P/c11-10-13-7-4(8(17)14-10)12-2-15(7)9-5(16)6-3(21-9)1-20-23(18,19)22-6/h2-3,5-6,9,16H,1H2,(H,18,19)(H3,11,13,14,17)
• Clé InChI: ZOOGRGPOEVQQDX-UHFFFAOYSA-N

Description

Actions biochimiques/physiologiques

An important second messenger, cGMP is a major intracellular mediator of extracellular signals such as nitric oxide and natriuretic peptides. Cyclic GMP interacts with three types of intracellular receptor proteins: cGMP-dependent protein kinases, cGMP-regulated channels, and cGMP-regulated cyclic nucleotide phosphodiesterases. A primary action of elevated cGMP levels in vivo is the stimulation of cGMP-dependent protein kinase (PKG).

Caractéristiques et avantages

This compound is a featured product for ADME Tox and Cyclic Nucleotide research. Discover more featured ADME Tox and Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Informations sur la sécurité

• Pictogrammes: GHS07
• Mention d'avertissement: Warning
• Mentions de danger: H315,H319,H335
• Conseils de prudence: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Classification des risques: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Organes cibles: Respiratory system
• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Équipement de protection individuelle: dust mask type N95 (US), Eyeshields, Gloves