I3265

Interferon-γ human

recombinant, expressed in E. coli, ≥98% (SDS-PAGE), lyophilized powder, suitable for cell culture

• Synonyme(s) : IFN-γ
• Numéro MDL: MFCD00131391
• Code UNSPSC : 12352202
• Nomenclature NACRES : NA.32

Propriétés

• Source biologique: human
• Niveau de qualité: 200
• Produit recombinant: expressed in E. coli
• Essai: ≥98% (SDS-PAGE)
• Forme: lyophilized powder
• Poids mol.: ~17 kDa
• Conditionnement: pkg of 0.1 mg
• Technique(s): cell culture | mammalian: suitable
• Impuretés: ≤1 EU/μg endotoxin
• Couleur: white
• Solubilité: water: soluble 1.000 mL, clear, colorless
• Numéro d'accès UniProt: P01579
• Température de stockage: −20°C
• Informations sur le gène: human ... IFNG(3458)

Description

Application

Interferon-γ human has been used:

• to study the effect of interferon-γ on cultured trophoblasts in absence and presence of fibronectin
• to analyse factors which participate in the production of antibody microarrays on glass support
• for ELISA (enzyme-linked immunosorbent assay) method to understand the effect of interferon-γ in human gingival fibroblasts in presence of bacterial challenge

Actions biochimiques/physiologiques

IFNG (interferon-γ) is a type-2 interferon which is produced by Th (T helper cells)-1 lymphocytes, CD8 cytotoxic lymphocytes, natural killer (NK) cells, and natural killer T (NKT) cells. It plays an important role in innate and adaptive immune responses, and helps in defense against bacterial infections, dimorphic yeast and some viral infections. High expression of IFNG is common in many autoimmune diseases, such as systemic lupus erythematosis, Sjögren syndrome, inflammatory bowel disease and multiple sclerosis.

Forme physique

Lyophilized from phosphate buffered saline.

Remarque sur l'analyse

The biological activity is measured by a viral resistance assay.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Gloves, type N95 (US)