L5163

Latrunculin A

from sea sponge, ≥85% (HPLC), waxy solid

• Synonyme(s) : LAT-A, [1R-[1R*, 4Z, 8E, 10Z, 12S*, 15R*, 17R*(R*)]]-4-(17-Hydroxy-5,12-dimethyl-3-oxo-2,16-dioxabicyclo[13.3.1]nonadeca-4,8,10-trien-17-yl)-2-thiazolidinone
• Formule empirique (notation de Hill) : C₂₂H₃₁NO₅S
• CAS Number: 76343-93-6
• Poids moléculaire : 421.55
• Code UNSPSC : 12352200
• ID de substance PubChem : 329817620
• Nomenclature NACRES : NA.77

Propriétés

• Source biologique: sea sponge
• Niveau de qualité: 200
• Essai: ≥85% (HPLC)
• Forme: waxy solid
• Poids mol.: 421.6
• Solubilité: DMSO: soluble; ethanol: soluble
• Température de stockage: −20°C
• Chaîne SMILES: C[C@H]1CC[C@@H]2C[C@H](C[C@@](O)(O2)[C@@H]3CSC(=O)N3)OC(=O)C=C(C)CC\C=C\C=C1
• InChI: 1S/C22H31NO5S/c1-15-7-5-3-4-6-8-16(2)11-20(24)27-18-12-17(10-9-15)28-22(26,13-18)19-14-29-21(25)23-19/h3-5,7,11,15,17-19,26H,6,8-10,12-14H2,1-2H3,(H,23,25)/b4-3+,7-5-,16-11-/t15-,17-,18-,19+,22-/m1/s1
• Clé InChI: DDVBPZROPPMBLW-IZGXTMSKSA-N

Description

Description générale

Latrunculin A, a toxin extracted from the red sea sponge Latrunculia magnifica. It participates in vitro in the morphological alteration of the polymerization of pure actin. It forms a complex by binding with the nucleotide cleft of actin for actin filaments elongation.

Application

Latrunculin A has been used as medium supplementation for A549 cells to determine the internalization mechanism of CAV9 in A549 human lung carcinoma cells.

Actions biochimiques/physiologiques

Latrunculin A inhibits actin polymerization by a different mechanism than cytochalasins. Latrunculin A disrupts microfilament-mediated processes.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Gloves, type N95 (US)