L9756

(−)-Tetramisole hydrochloride

powder, ≥99% (GC)

• Synonyme(s) : (S)-(−)-6-phényl-2,3,5,6-tétrahydroimidazo[2,1-b]thiazole hydrochloride, L(−)-2,3,5,6-tétrahydro-6-phénylimidazo(2,1-b)thiazole hydrochloride
• Formule empirique (notation de Hill) : C₁₁H₁₂N₂S · HCl
• CAS Number: 16595-80-5
• Poids moléculaire : 240.75
• Beilstein: 4358988
• Numéro CE : 240-654-6
• Numéro MDL: MFCD00012675
• Code UNSPSC : 12352202
• ID de substance PubChem : 24278526
• Nomenclature NACRES : NA.77

Propriétés

• Product Name: (−)-Tetramisole hydrochloride, ≥99% (GC)
• Source biologique: synthetic (organic)
• Niveau de qualité: 200
• Essai: ≥99% (GC)
• Forme: powder
• Pf: 228-230 °C
• Solubilité: water: 50 mg/mL, clear, colorless to faintly yellow
• Spectre d'activité de l'antibiotique: parasites
• Mode d’action: enzyme | inhibits
• Chaîne SMILES: Cl.C1CN2C[C@@H](N=C2S1)c3ccccc3
• InChI: 1S/C11H12N2S.ClH/c1-2-4-9(5-3-1)10-8-13-6-7-14-11(13)12-10;/h1-5,10H,6-8H2;1H/t10-;/m1./s1
• Clé InChI: LAZPBGZRMVRFKY-HNCPQSOCSA-N

Description

Application

Suitable for inhibition of various mammalian alkaline phosphatase (i.e., liver, kidney, placenta, bone and tumor).
Intestinal alkaline phosphatases are only slightly inhibited.
Not for veterinary use.

Actions biochimiques/physiologiques

Shows both immunostimulant and immunosuppressant effects, depending on several controllable factors. Very effective in treatment of ascariasis (hookworm infestation). Useful in chemotherapy of colorectal cancers, possibly due to its stimulation of IL-1 production and direct activation of macrophages.

Autres remarques

Levamisole hydrochloride is soluble in water at 50mg/mL yielding a clear, colorless solution. Solutions are stable at 2-8°C for ~1 month.

Informations sur la sécurité

• Pictogrammes: GHS06
• Mention d'avertissement: Danger
• Mentions de danger: H301
• Conseils de prudence: P301 + P310 + P330
• Classification des risques: Acute Tox. 3 Oral
• Code de la classe de stockage: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges