M2319

Mefloquine hydrochloride

≥98% (HPLC), powder

• Synonyme(s) : (AS)-rel-a-(2R)-2-Piperidinyl-2,8-bis(trifluoromethyl)-4-quinolinemethanol monohydrochloride
• Formule empirique (notation de Hill) : C₁₇H₁₇ClF₆N₂O
• CAS Number: 51773-92-3
• Poids moléculaire : 414.77
• Numéro CE : 257-412-0
• Numéro MDL: MFCD00797519
• Code UNSPSC : 12352202
• ID de substance PubChem : 24724536
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Essai: ≥98% (HPLC)
• Forme: powder
• Conditions de stockage: desiccated
• Couleur: white
• Solubilité: DMSO: soluble 38 mg/mL; H₂O: insoluble
• Chaîne SMILES: Cl[H].[H][C@@]1(CCCCN1)[C@@H](O)c2cc(nc3c(cccc23)C(F)(F)F)C(F)(F)F
• InChI: 1S/C17H16F6N2O.ClH/c18-16(19,20)11-5-3-4-9-10(15(26)12-6-1-2-7-24-12)8-13(17(21,22)23)25-14(9)11;/h3-5,8,12,15,24,26H,1-2,6-7H2;1H/t12-,15+;/m1./s1
• Clé InChI: WESWYMRNZNDGBX-YLCXCWDSSA-N

Description

Application

Mefloquine hydrochloride has been used:

• to treat cochlear organotypic cultures with various doses to evaluate its role in cellular pathway involved in apoptosis
• in screening for in vitro antischistosomal activity
• in cytotoxicity assay of glioblastoma cells

Actions biochimiques/physiologiques

Blocker of gap junction channels Cx36 and Cx50.

Mefloquine is broadly used as an antimalarial drug. It inhibits 80S ribosomes of Plasmodium. It has numerous side effects like anxiety, dizziness, tremor, headache, and hearing loss. Mefloquine damages cochlear and vestibular hair cells through apoptosis. It also damages spiral ganglion neurons, degenerates cortical neuron and disrupts neuronal calcium homeostasis.

Informations sur la sécurité

• Pictogrammes: GHS07
• Mention d'avertissement: Warning
• Mentions de danger: H302
• Conseils de prudence: P264 - P270 - P301 + P312 - P501
• Classification des risques: Acute Tox. 4 Oral
• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: dust mask type N95 (US), Eyeshields, Gloves