M5571

Miltefosine

≥98% (perchloric acid titration)

• Synonyme(s) : Choline hexadecyl phosphate, HePC, Hexadecyl phosphocholine
• Formule empirique (notation de Hill) : C₂₁H₄₆NO₄P
• CAS Number: 58066-85-6
• Poids moléculaire : 407.57
• Numéro MDL: MFCD00133396
• Code UNSPSC : 51191904
• ID de substance PubChem : 329818017
• Nomenclature NACRES : NA.85

Propriétés

• Source biologique: synthetic (organic)
• Niveau de qualité: 200
• Description: zwitterionic
• Essai: ≥98% (perchloric acid titration)
• Forme: powder
• Solubilité: H₂O: 10 mg/mL, clear, colorless
• Groupe fonctionnel: phospholipid
• Type de lipide: phospholipids
• Température de stockage: room temp
• Chaîne SMILES: [O-]P(OCC[N+](C)(C)C)(OCCCCCCCCCCCCCCCC)=O
• InChI: 1S/C21H46NO4P/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-20-25-27(23,24)26-21-19-22(2,3)4/h5-21H2,1-4H3
• Clé InChI: PQLXHQMOHUQAKB-UHFFFAOYSA-N

Description

Application

• Easy one-pot synthesis of multifunctionalized indole-pyrrole hybrids as a new class of antileishmanial agents.: This study underlines the necessity for innovative treatments amidst growing resistance to established drugs such as miltefosine which is used as a positive control reference, potentially setting a new direction for antileishmanial drug development (Ciccone et al., 2024).

Actions biochimiques/physiologiques

Inhibitor of protein kinase C and of phosphatidylcholine synthesis. Used for the treatment of visceral and cutaneous leishmaniasis. Active against metronidazole-resistant and -susceptible strains of Trichomonas vaginalis

Informations sur la sécurité

• Pictogrammes: GHS06
• Mention d'avertissement: Danger
• Mentions de danger: H301
• Conseils de prudence: P264 - P270 - P301 + P310 - P405 - P501
• Classification des risques: Acute Tox. 3 Oral
• Code de la classe de stockage: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Classe de danger pour l'eau (WGK): WGK 3
• Équipement de protection individuelle: dust mask type N95 (US), Eyeshields, Faceshields, Gloves