O3139

Oxamflatin

≥98% (HPLC), solid

• Synonyme(s) : (2E)-5-[3-(Phenylsulfonylamino)phenyl]-pent-2-en-4-ynohydroxamic acid
• Formule empirique (notation de Hill) : C₁₇H₁₄N₂O₄S
• CAS Number: 151720-43-3
• Poids moléculaire : 342.37
• Numéro MDL: MFCD00949087
• Code UNSPSC : 12352203
• ID de substance PubChem : 329818905
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Essai: ≥98% (HPLC)
• Forme: solid
• Solubilité: DMSO: soluble 13 mg/mL
• Température de stockage: 2-8°C
• Chaîne SMILES: ONC(=O)\C=C\C#Cc1cccc(NS(=O)(=O)c2ccccc2)c1
• InChI: 1S/C17H14N2O4S/c20-17(18-21)12-5-4-7-14-8-6-9-15(13-14)19-24(22,23)16-10-2-1-3-11-16/h1-3,5-6,8-13,19,21H,(H,18,20)/b12-5+
• Clé InChI: QRPSQQUYPMFERG-LFYBBSHMSA-N

Description

Application

Oxamflatin has been used as a histone deacetylase (HDAC) inhibitor:

• to study its effect on specificity protein 1 (Sp1) transcription and transactivation activity and CD1d mRNA expression in various tumor cells
• to study its inhibitory effect on long transcript- survival motor neuron gene 2 (SMN2) silencing mediated by DNA methylation
• to study its effect on somatic embryogenesis in Coffea arabica thorough a miniaturized and automated screening system
• to study its stand-alone effect on cytarabine-sensitive and resistant cells.

Actions biochimiques/physiologiques

Histone deacetylase inhibitor; anti-cancer agent.

Oxamflatin is an aromatic sulfonamide derivative with a hydroxamic acid group. It stimulates the expression of the transcription factor, JunD, and fibronectin. In addition, oxamflatin also aids in the morphological reversion of various NIH3T3-derived transformed cell lines. It inhibits the proliferation of various mouse and human tumor cell lines in vitro.

Caractéristiques et avantages

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Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Gloves, type N95 (US)