O9265

Osthole

• Synonyme(s) : 7-Methoxy-8-(3-methyl-2-butenyl)coumarin, 7-Methoxy-8-isopentenylcoumarin, Osthol
• Formule empirique (notation de Hill) : C₁₅H₁₆O₃
• CAS Number: 484-12-8
• Poids moléculaire : 244.29
• Numéro MDL: MFCD00076049
• Code UNSPSC : 12352205
• ID de substance PubChem : 329818938
• Nomenclature NACRES : NA.25

Propriétés

• Essai: ≥95% (HPLC)
• Niveau de qualité: 200
• Forme: powder
• Couleur: white
• Solubilité: methanol: soluble 10 mg/mL, clear, colorless
• Application(s): metabolomics; vitamins, nutraceuticals, and natural products
• Température de stockage: room temp
• Chaîne SMILES: COc1ccc2C=CC(=O)Oc2c1C\C=C(\C)C
• InChI: 1S/C15H16O3/c1-10(2)4-7-12-13(17-3)8-5-11-6-9-14(16)18-15(11)12/h4-6,8-9H,7H2,1-3H3
• Clé InChI: MBRLOUHOWLUMFF-UHFFFAOYSA-N

Description

Actions biochimiques/physiologiques

Active constituent of Cnidium monnieri, a traditional Chinese medicine used for its anti-inflammatory, analgesic, and anti-lipedemic activities. Dramatically decreased lipid accumulation in a quail model. Its neuroprotective effect on MPP(+)-induced cytotoxicity in PC12 cells supports the use of osthole as a therapeutic agent for the treatment of neurodegenerative disorders. Suppression of fatty acid synthase expression in HER2-overexpressing breast cancer cells indicates osthole as a promising agent for chemotherapy.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable