P3235

Prostate Specific Antigen from human semen

buffered aqueous solution

• Synonyme(s) : Cancer-associated PSA, PSA
• Numéro MDL: MFCD00165544
• Code UNSPSC : 12352202
• Nomenclature NACRES : NA.32

Propriétés

• Source biologique: human semen
• Niveau de qualité: 200
• Essai: ≥99% (SDS-GE)
• Forme: buffered aqueous solution
• Numéro d'accès UniProt: P07288
• Conditions d'expédition: wet ice
• Température de stockage: −20°C
• Informations sur le gène: human ... KLK3(354)

Description

Description générale

Prostate specific antigen (PSA) is a 26kDa single-chain glycoprotein containing 237 amino acids, encoded by the kallikrein gene mapped to human chromosome 19. It is specifically expressed by human prostate tissue and is a highly abundant proteolytic enzyme expressed in the seminal fluid.

Actions biochimiques/physiologiques

Glycoprotein of the glandular kallikrein family

Prostate Specific Antigen (PSA), a glycoprotein of the glandular kallikrein family, is a serine protease with chymotrypsin-like enzymatic activity. Circulating PSA exists in free and protease inhibitor-bound forms. Studying the ratios of free to inhibitor-bound forms may prove valuable in the diagnosis of prostate cancer.

Prostate-specific antigen (PSA) is an androgen-regulated serine protease specifically produced by prostatic tissue and is secreted into the lumen. PSA in semen cleaves semenogelins present in the seminal coagulum. Total PSA levels are increased in serum of prostate cancer (PCa) patients. PSA functions as a potential biomarker for PCa. Serum protease inhibitors such as α1-antichymotrypsin (α1-ACT), α2-macroglobulin (α2-M) and other acute-phase proteins form irreversible complexes with circulating PSA and hinder proteolytic activity of PSA.

Forme physique

Solution in 10 mM Tris, 0.1% sodium azide, pH 8.0

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable