R7269

Rhein

≥98% (HPLC), powder, cytotoxic agent

• Synonyme(s) : 4,5-Dihydroxyanthraquinone-2-carboxylic acid, 9,10-Dihydro-4,5-dihydroxy-9,10-dioxo-2-anthracenecarboxylic acid, Cassic acid, Chrysazin 3-carboxylic acid, Monorhein, Rheic acid, Rhubarb yellow
• Formule empirique (notation de Hill) : C₁₅H₈O₆
• CAS Number: 478-43-3
• Poids moléculaire : 284.22
• Beilstein: 2222155
• Numéro CE : 207-521-4
• Numéro MDL: MFCD00009618
• Code UNSPSC : 12352200
• ID de substance PubChem : 24899390
• Nomenclature NACRES : NA.77

Propriétés

• Product Name: Rhein,
• Niveau de qualité: 100
• Pf: ≥300 °C (lit.)
• Température de stockage: 2-8°C
• Chaîne SMILES: OC(=O)c1cc(O)c2C(=O)c3c(O)cccc3C(=O)c2c1
• InChI: 1S/C15H8O6/c16-9-3-1-2-7-11(9)14(19)12-8(13(7)18)4-6(15(20)21)5-10(12)17/h1-5,16-17H,(H,20,21)
• Clé InChI: FCDLCPWAQCPTKC-UHFFFAOYSA-N

Description

Application

Rhein has been used:

• as a potassium simplex optimization medium with amino acids (KSOMaa) to induce degeneration in embryos to study its effect on the intracellular and extracellular micro-RNA (miRNA) signature
• as a fat mass and obesity-associated protein (FTO) inhibitor to study its role in motile ciliogenesis in an m6A-dependent manner in Xenopus embryos
• as an FTO inhibitor to infer its antiviral action in relation with the SARS-associated coronavirus 2 (SARS-CoV-2) infection

Actions biochimiques/physiologiques

Rhein, a cytotoxic agent, exhibits tumor suppression by activating apoptosis. It is a selective inhibitor of demethylase fat mass and obesity-associated protein (FTO). Rhein is known to participate in various biological processes including obesity and adipogenesis.

Informations sur la sécurité

• Pictogrammes: GHS07
• Mention d'avertissement: Warning
• Mentions de danger: H315,H319,H335
• Conseils de prudence: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Classification des risques: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Organes cibles: Respiratory system
• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 2
• Équipement de protection individuelle: dust mask type N95 (US), Eyeshields, Gloves