S4503

DL-Serine hydroxamate

≥97% (TLC), suitable for ligand binding assays

• Synonyme(s) : SHX
• Formule empirique (notation de Hill) : C₃H₈N₂O₃
• CAS Number: 55779-32-3
• Poids moléculaire : 120.11
• Numéro MDL: MFCD00055712
• Code UNSPSC : 12352209
• ID de substance PubChem : 24899606
• Nomenclature NACRES : NA.26

Propriétés

• Product Name: DL-Serine hydroxamate, seryl-tRNA synthetase inhibitor
• Niveau de qualité: 200
• Essai: ≥97% (TLC)
• Forme: powder
• Technique(s): ligand binding assay: suitable
• Couleur: white to off-white
• Application(s): cell analysis
• Température de stockage: −20°C
• Chaîne SMILES: NC(CO)C(=O)NO
• InChI: 1S/C3H8N2O3/c4-2(1-6)3(7)5-8/h2,6,8H,1,4H2,(H,5,7)
• Clé InChI: LELJBJGDDGUFRP-UHFFFAOYSA-N

Description

Application

Serine has been used as an inhibitor of seryl-tRNA synthetase. DL-Serine hydroxamate is used to induce metabolic synthesis of guanosine 3′-diphosphate 5′-diphosphate (ppGpp) in E. coli by amino acid starvation. It is also used to synchronize cell cycle in E. coli cultures by inhibition of tRNA charging.

Actions biochimiques/physiologiques

Serine is involved in the one-carbon unit metabolism. It is associated with the biosynthesis of cysteine, ceramide, phosphatidylserine, purine and pyrimidine. In bacteria, it participates in tryptophan synthesis. Gluconeogenesis, one of the important biochemical processes, involves serine, particularly in ruminants. Protein phosphorylation is one such event that utilizes serine. Glycine, a metabolic product of serine, serves as an antioxidant and a neurotransmitter. D-serine is known to activate the N-methyl-D-aspartate (NMDA) receptors of the brain. Serine hydroxamate, a structural analogue of serine prevents seryl-tRNA (transfer ribonucleic acid) charging and thereby decreases phospholipid and nucleic acid synthesis in Escherichia coli.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Gloves, type N95 (US)