S8626

Sulfadiazine

99.0-101.0%

• Synonyme(s) : 4-Amino-N-(2-pyrimidinyl)benzenesulfonamide, N¹-(Pyrimidin-2-yl)sulfanilamide
• Formule empirique (notation de Hill) : C₁₀H₁₀N₄O₂S
• CAS Number: 68-35-9
• Poids moléculaire : 250.28
• Beilstein: 6733588
• Numéro CE : 200-685-8
• Numéro MDL: MFCD00006065
• Code UNSPSC : 51283908
• ID de substance PubChem : 24899802
• Nomenclature NACRES : NA.85

Propriétés

• Description: Solubility - Practically insoluble in water, slightly soluble in acetone, very slightly soluble in ethanol (96 per cent). It dissolves in solutions of alkali hydroxides and in dilute mineral acids.
• Niveau de qualité: 200
• Essai: 99.0-101.0%
• Forme: powder or crystals
• Couleur: white to faint yellow, faint pink
• Pf: 253 °C (dec.) (lit.)
• Solubilité: 96% ethanol: very slightly soluble; acetone: slightly soluble; water: practically insoluble
• Spectre d'activité de l'antibiotique: Gram-negative bacteria; Gram-positive bacteria; mycoplasma
• Mode d’action: DNA synthesis | interferes; enzyme | inhibits
• Chaîne SMILES: Nc1ccc(cc1)S(=O)(=O)Nc2ncccn2
• InChI: 1S/C10H10N4O2S/c11-8-2-4-9(5-3-8)17(15,16)14-10-12-6-1-7-13-10/h1-7H,11H2,(H,12,13,14)
• Clé InChI: SEEPANYCNGTZFQ-UHFFFAOYSA-N

Description

Description générale

Chemical structure: sulfonamide

Application

Sulfadiazine is a short-acting sulfonamide that is commonly used with pyrimethamine to treat toxoplasmosis in patients with acquired immunodeficiency syndrome. It is also used to treat newborns with congenital infections. Sulfadiazine has been used to control acute infections when studying murine models of reactivated toxoplasmosis.

Actions biochimiques/physiologiques

Sulfadiazine is a sulfonamide antibiotic that blocks the synthesis of dihydrofolic acid by inhibiting the enzyme dihydropteroate synthase. Sulfadiazine is a competitive inhibitor of bacterial para-aminobenzoic acid (PABA), which is required for bacterial synthesis of folic acid. It is active against Gram positive bacteria, Gram negative bacteria and Chlamydia. Mode of resistance is via the alteration of dihydropteroate synthase or alternative pathway for folic acid synthesis.

Autres remarques

Keep container tightly closed in a dry and well-ventilated place.Storage class (TRGS 510): Non Combustible Solids

Informations sur la sécurité

• Pictogrammes: GHS08,GHS07,GHS09
• Mention d'avertissement: Warning
• Mentions de danger: H302,H361d,H411
• Conseils de prudence: P202 - P264 - P273 - P280 - P301 + P312 - P308 + P313
• Classification des risques: Acute Tox. 4 Oral - Aquatic Chronic 2 - Repr. 2
• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 2
• Équipement de protection individuelle: dust mask type N95 (US), Eyeshields, Faceshields, Gloves