SML0789

GI254023X

≥98% (HPLC), powder, ADAM10 metalloproteinase inhibitor

• Synonyme(s) : (2R)-N-[(1S)-2,2-Dimethyl-1-[(methylamino)carbonyl]-propyl]-2-[(1S)-1-[formyl(hydroxy)amino]ethyl]-5-phenylpentanamide, GI4023
• Formule empirique (notation de Hill) : C₂₁H₃₃N₃O₄
• CAS Number: 260264-93-5
• Poids moléculaire : 391.50
• Numéro MDL: MFCD19381832
• Code UNSPSC : 12352200
• ID de substance PubChem : 329825599
• Nomenclature NACRES : NA.77

Propriétés

• Product Name: GI254023X, ≥98% (HPLC)
• Niveau de qualité: 100
• Essai: ≥98% (HPLC)
• Forme: powder
• Couleur: white to beige
• Solubilité: DMSO: 15 mg/mL, clear
• Température de stockage: 2-8°C
• Chaîne SMILES: ON(C=O)[C@@H](C)[C@@H](CCCC1=CC=CC=C1)C(N[C@@H](C(C)(C)C)C(NC)=O)=O
• InChI: 1S/C21H33N3O4/c1-15(24(28)14-25)17(13-9-12-16-10-7-6-8-11-16)19(26)23-18(20(27)22-5)21(2,3)4/h6-8,10-11,14-15,17-18,28H,9,12-13H2,1-5H3,(H,22,27)(H,23,26)/t15-,17+,18+/m0/s1
• Clé InChI: GHVMTHKJUAOZJP-CGTJXYLNSA-N

Description

Application

GI254023X has been used to inhibit ADAM10 (ADAM metallopeptidase domain 10).

Actions biochimiques/physiologiques

GI254023X blocks ADAM10 (ADAM metallopeptidase domain 10) activity and decreases human leukocyte antigen (HLA)-mediated cytotoxicity and cleavage of extracellular E-cadherin in epithelial and endothelial cells.

GI254023X is a potent and selective ADAM10 metalloproteinase inhibitor with 100-fold selectivity for the α-secretase ADAM10 over ADAM17 (TACE). In a study using recombinant TACE and ADAM10 ectodomain, the IC₅₀ for GI254023X was 5.3 nM for ADAM10 vs 541 nM for TACE.

GI254023X is a potent and selective ADAM10 metalloproteinase inhibitor.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable