SML2437

H-151

≥98% (HPLC)

• Synonyme(s) : 1-(4-Ethylphenyl)-3-(1H-indol-3-yl) urea
• Formule empirique (notation de Hill) : C₁₇H₁₇N₃O
• CAS Number: 941987-60-6
• Poids moléculaire : 279.34
• Numéro MDL: MFCD08026581
• Code UNSPSC : 12352200
• Nomenclature NACRES : NA.77

Propriétés

• Essai: ≥98% (HPLC)
• Forme: powder
• Couleur: white to beige
• Solubilité: DMSO: 2 mg/mL, clear
• Température de stockage: 2-8°C
• Chaîne SMILES: [nH]1c2c(c(c1)NC(=O)Nc3ccc(cc3)CC)cccc2
• InChI: 1S/C17H17N3O/c1-2-12-7-9-13(10-8-12)19-17(21)20-16-11-18-15-6-4-3-5-14(15)16/h3-11,18H,2H2,1H3,(H2,19,20,21)
• Clé InChI: UJZDIKVQFMCLBE-UHFFFAOYSA-N

Description

Actions biochimiques/physiologiques

Antagonist of the stimulator of interferon genes (STING) protein

H-151 is an irreversible antagonist of the stimulator of interferon genes (STING) protein, a central signalling component of the cytosolic DNA sensing pathway. Although STING is a vital component of the innate immune pathways, it has also been shown to have a pathogenic role in some inflammatory diseases. H-151 is a potent and selective STING antagonist with inhibitory activity both in human cells and in vivo in mice. Given as a pretreatment, H-151 was shown to attenuate pathological features of autoinflammatory disease in mouse models, reducing systemic cytokine responses in mice treated with the STING agonist 10-carboxymethyl-9-acridanone (CMA)

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable