D5817

DMXAA

≥98% (HPLC), solid, apoptosis inducer

• Synonyme(s) : 5,6-Dimethylxanthenone-4-acetic Acid, ASA404, Vadimezan
• Formule empirique (notation de Hill) : C₁₇H₁₄O₄
• CAS Number: 117570-53-3
• Poids moléculaire : 282.29
• Numéro MDL: MFCD00870555
• Code UNSPSC : 12352200
• ID de substance PubChem : 24724464
• Nomenclature NACRES : NA.77

Propriétés

• Product Name: DMXAA, ≥98% (HPLC), solid
• Niveau de qualité: 100
• Essai: ≥98% (HPLC)
• Forme: solid
• Couleur: light brown
• Solubilité: DMSO: soluble >10 mg/mL
• Température de stockage: 2-8°C
• Chaîne SMILES: Cc1ccc2C(=O)c3cccc(CC(O)=O)c3Oc2c1C
• InChI: 1S/C17H14O4/c1-9-6-7-13-15(20)12-5-3-4-11(8-14(18)19)17(12)21-16(13)10(9)2/h3-7H,8H2,1-2H3,(H,18,19)
• Clé InChI: XGOYIMQSIKSOBS-UHFFFAOYSA-N

Description

Description générale

5,6-dimethylxanthenone-4-acetic acid (DMXAA) is a flavone acetic acid derivative. It acts as a vascular disrupting agent (VDA), which damages tumor vasculature and stimulates an anti-tumor immune response. It stimulates hemorrhagic necrosis.

Application

5,6-dimethylxanthenone-4-acetic acid (DMXAA) has been used to induce type-I IFN signaling in a stimulator of interferon genes (STING) dependent manner. It has also been used to study STING-dependent signaling in the absence of infection.

Actions biochimiques/physiologiques

DMXAA is an apoptosis inducer; anti-vascular.

Caractéristiques et avantages

This compound is a featured product for Apoptosis research. Click here to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Informations sur la sécurité

• Pictogrammes: GHS07,GHS09
• Mention d'avertissement: Warning
• Mentions de danger: H302,H400
• Conseils de prudence: P273 - P301 + P312 + P330
• Classification des risques: Acute Tox. 4 Oral - Aquatic Acute 1
• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: dust mask type N95 (US), Eyeshields, Faceshields, Gloves