SRP8029

Flagellin from Salmonella typhimurium

>95% (SDS-PAGE)

• Synonyme(s) : FliC, Intelectin-1
• CAS Number: 12777-81-0
• Code UNSPSC : 12352202
• Nomenclature NACRES : NA.32

Propriétés

• Source biologique: Salmonella enterica subsp. enterica serovar Typhimurium str. LT2
• Essai: >95% (SDS-PAGE)
• Forme: lyophilized
• Poids mol.: ~50 kDa by SDS-PAGE
• Conditionnement: pkg of 10 μg
• Impuretés: <0.01 EU/μg endotoxin, tested
• Couleur: white
• Numéro d'accès UniProt: P06179
• Conditions d'expédition: wet ice
• Température de stockage: −20°C
• Informations sur le gène: Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 ... fliC (STM1959)

Description

Description générale

FliC (flagellin) is the subunit protein which polymerizes to form the filaments of bacterial flagella. The protein has four-domains (D0, D1, D2, D3).

The encoded flagellin filament contains 55 kDa monomers.

Actions biochimiques/physiologiques

FliC (flagellin) can activate the innate immune system by TLR5 (toll like receptor 5) and is an important proinflammatory molecule. FliC also induces the production of antibodies and is identified as an antigen by CD⁴⁺ T cells.

It also stimulates the production of proinflammatory mediators : nitric oxide, interleukin 1 (IL-1), IL-6, IL-8, and tumor necrosis factor α.

Forme physique

Lyophilized from PBS.

Reconstitution

Reconstitute with 100 μL deionized water.

Informations sur la sécurité

• Code de la classe de stockage: 10 - Combustible liquids
• Classe de danger pour l'eau (WGK): WGK 2
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable