T7205

Tegafur

≥98% (HPLC), powder

• Synonyme(s) : 5-Fluoro-1-(tetrahydro-2-furyl)uracil, Ftorafur, Tegafur
• Formule empirique (notation de Hill) : C₈H₉FN₂O₃
• CAS Number: 17902-23-7
• Poids moléculaire : 200.17
• Numéro CE : 241-846-2
• Numéro MDL: MFCD00012351
• Code UNSPSC : 12352200
• ID de substance PubChem : 329826861
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Essai: ≥98% (HPLC)
• Forme: powder
• Couleur: white to off-white
• Pf: 171-173 °C (lit.)
• Solubilité: DMSO: >50 mg/mL
• Température de stockage: room temp
• Chaîne SMILES: FC1=CN(C2CCCO2)C(=O)NC1=O
• InChI: 1S/C8H9FN2O3/c9-5-4-11(6-2-1-3-14-6)8(13)10-7(5)12/h4,6H,1-3H2,(H,10,12,13)
• Clé InChI: WFWLQNSHRPWKFK-UHFFFAOYSA-N

Description

Application

Tegafur has been used as an internal standard for the analysis of 5′DFCR (5′deoxyfluorocytidine) and 5′DFUR (5′deoxyfluorouridine) using HPLC techniques. Tegafur has also been used as an internal standard for the chromatographic assay of azidothymidine (AZT).

Actions biochimiques/physiologiques

Tegafur is a pro-drug of 5-fluorouracil, an antimetabolite used as an antineoplastic agent. It has been used as adjuvant chemotherapy for curatively resected colorectal cancer therapy.

Notes préparatoires

Tegafur is soluble in DMSO at a concentration that is greater than 50 mg/ml.

Informations sur la sécurité

• Pictogrammes: GHS06
• Mention d'avertissement: Danger
• Mentions de danger: H301 + H311 + H331
• Conseils de prudence: P261 - P264 - P280 - P301 + P310 - P302 + P352 + P312 - P304 + P340 + P311
• Classification des risques: Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral
• Code de la classe de stockage: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable