U1008

Urocortin III human

≥97% (HPLC)

• Empirical Formula (Hill Notation): C₁₈₅H₃₀₇N₅₃O₅₀S₂
• CAS Number: 351999-19-4
• Molecular Weight: 4137.87
• MDL number: MFCD03792654
• UNSPSC Code: 12352200
• NACRES: NA.32

Properties

• biological source: human
• Quality Level: 200
• Assay: ≥97% (HPLC)
• form: solid
• technique(s): ligand binding assay: suitable
• UniProt accession no.: Q969E3
• storage temp.: −20°C
• Gene Information: human ... UCN3(114131)

Description

Amino Acid Sequence

Phe-Thr-Leu-Ser-Leu-Asp-Val-Pro-Thr-Asn-Ile-Met-Asn-Leu-Leu-Phe-Asn-Ile-Ala-Lys-Ala-Lys-Asn-Leu-Arg-Ala-Gln-Ala-Ala-Ala-Asn-Ala-His-Leu-Met-Ala-Gln-Ile-NH2

Application

Urocortin III human can be used as a test compound for studying the impacts of melanocortin agonist on in vitro α-subunit secretion.

Biochem/physiol Actions

Selective ligand with high affinity for CRF2 Receptors

Urocortin III belongs to corticotropin-releasing hormone family with high affinity for the type 2 corticotropin-releasing factor (CRFR2) receptor. It stimulates insulin and glucagon secretion.Urocortin III also possesses cardioprotective property and has minimal impact on the hypothalamic stress axis. It is, therefore, utilized for treating ischemic heart disease.

Other Notes

Lyophilized from 0.1% TFA in H2O

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable