U4127

Urocortin human

≥85% (HPLC), powder

• Empirical Formula (Hill Notation): C₂₀₄H₃₃₇N₆₃O₆₄
• CAS Number: 176591-49-4
• Molecular Weight: 4696.24
• MDL number: MFCD00802621
• UNSPSC Code: 12352200
• NACRES: NA.32

Properties

• biological source: human
• Quality Level: 200
• Assay: ≥85% (HPLC)
• form: powder
• technique(s): ligand binding assay: suitable
• UniProt accession no.: P55089
• storage temp.: −20°C
• Gene Information: human ... UCN(7349)

Description

Amino Acid Sequence

Asp-Asn-Pro-Ser-Leu-Ser-Ile-Asp-Leu-Thr-Phe-His-Leu-Leu-Arg-Thr-Leu-Leu-Glu-Leu-Ala-Arg-Thr-Gln-Ser-Gln-Arg-Glu-Arg-Ala-Glu-Gln-Asn-Arg-Ile-Ile-Phe-Asp-Ser-Val-NH2

Application

Urocortin human can be used as a test compound for studying the impact of corticotropin-releasing factor (CRF) receptor agonist and antagonist on sleep-wake patterns in conscious rats by using radiotelemetry system.

Biochem/physiol Actions

Binds to CRF receptor types 1, 2α, and 2β.

Binds to CRF receptor types 1, 2α, and 2β; stimulates cAMP accumulation from cells transfected with these receptors. Acts in vitro to release ACTH from rat anterior pituitary cells.

Urocortin is a CRF-related neuropeptide having high affinity for CRF2 receptor possess appetite-suppressing effect. Urocortin along with corticotropin-releasing factor (CRF) binding protein (CRF-BP) enhances the free CRF levels in human brain by displacing hCRF from the binding protein.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves