275875

4-Aminopyridine

≥99%

• 동의어(들): 4-Pyridinamine, 4-Pyridylamine, 4AP, Fampridine
• 실험식(Hill 표기법): C₅H₆N₂
• CAS Number: 504-24-5
• Molecular Weight: 94.11
• Beilstein: 105782
• EC Number: 207-987-9
• MDL number: MFCD00006439
• UNSPSC 코드: 12352100
• PubChem Substance ID: 24856677
• NACRES: NA.22

속성

• 분석: ≥99%
• 양식: solid
• bp: 273 °C (lit.)
• mp: 155-158 °C (lit.)
• solubility: DMF: soluble(lit.); DMSO: soluble(lit.); THF: soluble(lit.); acetone: soluble(lit.); acetonitrile: soluble(lit.); ethanol: soluble(lit.); isopropanol: soluble(lit.); methanol: soluble(lit.); water: soluble(lit.)
• SMILES string: Nc1ccncc1
• InChI: 1S/C5H6N2/c6-5-1-3-7-4-2-5/h1-4H,(H2,6,7)
• InChI key: NUKYPUAOHBNCPY-UHFFFAOYSA-N
• 유전자 정보: human ... KCNA1(3736), KCNA10(3744), KCNA2(3737), KCNA3(3738), KCNA4(3739), KCNA5(3741), KCNA6(3742), KCNA7(3743), KCNB1(3745), KCNB2(9312), KCNC1(3746), KCNC2(3747), KCNC3(3748), KCNC4(3749), KCND1(3750), KCND2(3751), KCND3(3752), KCNF1(3754), KCNG1(3755), KCNG2(26251), KCNG3(170850), KCNG4(93107), KCNH1(3756), KCNH2(3757), KCNH3(23416), KCNH4(23415), KCNH5(27133), KCNH6(81033), KCNH7(90134), KCNH8(131096), KCNQ1(3784), KCNQ2(3785), KCNQ3(3786), KCNQ4(9132), KCNQ5(56479), KCNS1(3787), KCNS2(3788), KCNS3(3790), KCNV1(27012), KCNV2(169522) ; mouse ... Kcna3(16491) ; rat ... Grin2a(24409)

설명

일반 설명

4-Aminopyridine (4-AP) blocks the voltage-dependent potassium channels in other nerve membranes. 4-AP is a K⁺ channel blocker and causes epileptiform activity in in vitro preparations and is a potent convulsant in animals and man.

애플리케이션

4-Aminopyridine can be used as:

• A reactant to prepare pharmacologically important 4-amino-N-pyridin-4-yl-butyramide hydrochloride.
• A reactant to prepare cinnamic acid derivatives as potent cholinesterase inhibitors.
• A starting material to prepare aza analogs of batracylin, a topoisomerase II inhibitor.

안전성 정보

• 픽토그램: GHS06,GHS05,GHS09
• 신호어: Danger
• 유해 및 위험 성명서: H300,H311 + H331,H314,H411
• 예방조치 성명서: P260 - P273 - P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 2 Oral - Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Aquatic Chronic 2 - Eye Dam. 1 - Skin Corr. 1B
• Storage Class Code: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• WGK: WGK 3
• Flash Point (°F): 312.8 °F
• Flash Point (°C): 156 °C
• 개인 보호 장비: dust mask type N95 (US), Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges