764493

5-[4-(1,2,4,5-Tetrazin-3-yl)benzylamino]-5-oxopentanoic acid

97%

• 동의어(들): 5-Oxo-5-[[[4-(1,2,4,5-tetrazin-3-yl)phenyl]methyl]amino]pentanoic acid, Benzylamino tetrazine acid, Bz-Tz-acid
• 실험식(Hill 표기법): C₁₄H₁₅N₅O₃
• CAS Number: 1225146-53-1
• Molecular Weight: 301.30
• MDL number: MFCD23098727
• UNSPSC 코드: 12352200
• PubChem Substance ID: 329767124
• NACRES: NA.22

속성

• 분석: 97%
• 양식: solid
• 반응 적합성: reaction type: click chemistry; reagent type: linker
• mp: 163-170 °C (decomposition)
• 작용기: carboxylic acid
• 저장 온도: −20°C
• SMILES string: OC(CCCC(NCC(C=C1)=CC=C1C2=NN=CN=N2)=O)=O
• InChI: 1S/C14H15N5O3/c20-12(2-1-3-13(21)22)15-8-10-4-6-11(7-5-10)14-18-16-9-17-19-14/h4-7,9H,1-3,8H2,(H,15,20)(H,21,22)
• InChI key: KWNYIZNORNUUJQ-UHFFFAOYSA-N

설명

애플리케이션

5-[4-(1,2,4,5-Tetrazin-3-yl)benzylamino]-5-oxopentanoic acid may be used in the synthesis of a PEG-tetrazine (PEG-Tz) macromer via acid-amine conjugation. This macromer can undergo click reaction with norbornene-functionalized peptides to form hydrogels that is useful for 3D cell culture.

Acid functionalized tetrazine for inverse electron demand Diels-Alder cycloaddition reactions. The tetrazine will react with strained alkenes such as transcyclooctene, norbornene and cyclopropene to yield a stable covalent linkage. Tetrazines have proven useful in bioorthogonal reactions for many biological imaging and bioconjugation applications.

안전성 정보

• 픽토그램: GHS07
• 신호어: Warning
• 유해 및 위험 성명서: H302,H315,H319,H335
• 예방조치 성명서: P261 - P264 - P271 - P301 + P312 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• 표적 기관: Respiratory system
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable