790435

TCO PEG4 succinimidyl ester

• 동의어(들): trans-Cyclooctene-PEG4-NHS
• 실험식(Hill 표기법): C₂₄H₃₈N₂O₁₀
• Molecular Weight: 514.57
• MDL number: MFCD28118912
• UNSPSC 코드: 12352108
• PubChem Substance ID: 329768214
• NACRES: NA.22

속성

• 양식: liquid
• Quality Level: 100
• 반응 적합성: reaction type: click chemistry; reagent type: linker
• 작용기: NHS ester
• 저장 온도: −20°C
• SMILES string: O=C(NCCOCCOCCOCCOCCC(ON1C(CCC1=O)=O)=O)OC2CCC/C=C/CC2
• InChI: 1S/C24H38N2O10/c27-21-8-9-22(28)26(21)36-23(29)10-12-31-14-16-33-18-19-34-17-15-32-13-11-25-24(30)35-20-6-4-2-1-3-5-7-20/h1-2,20H,3-19H2,(H,25,30)/b2-1+
• InChI key: ZKPMRASGLDBKPF-OWOJBTEDSA-N

설명

애플리케이션

Succinimidyl ester/NHS (amine reactive) functionalized trans-cyclooctene derivative for incorporation of the cyclooctene moiety into amine containing compounds or biomolecules. Trans-cyclooctenes are useful in strain-promoted, copper-free, click chemistry cycloaddition reactions with 1, 2, 4, 5-tetrazines. This cyclooctene will react with tetrazine functionalized compounds or biomolecules, without the need for a catalyst, to result in a stable covalent linkage. The 4+2 inverse electron demand Diels-Alder cycloaddition between trans-cyclooctene and tetrazines is the fastest biologically compatible ligation technology reported, and has had many applications in biological labeling and imaging. The PEG spacer allows for increased water solubility, less aggregation, and an increased distance between the amine to be modified and the reactive alkene.

안전성 정보

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable