902659

Amino-PEG6-t-butyl ester

• 동의어(들): tert-Butyl 1-amino-3,6,9,12,15,18-hexaoxahenicosan-21-oate, H₂N-PEG6-CH₂CH₂COOtBu
• 실험식(Hill 표기법): C₁₉H₃₉NO₈
• CAS Number: 1286281-32-0
• Molecular Weight: 409.51
• MDL number: MFCD13184944
• UNSPSC 코드: 51171641
• NACRES: NA.22

속성

• 양식: liquid
• 반응 적합성: reagent type: cross-linking reagent
• refractive index: n/D 1.4562
• density: 1.06581 g/mL
• 작용기: amine; ester
• 저장 온도: −20°C
• SMILES string: NCCOCCOCCOCCOCCOCCOCCC(OC(C)(C)C)=O
• InChI: 1S/C19H39NO8/c1-19(2,3)28-18(21)4-6-22-8-10-24-12-14-26-16-17-27-15-13-25-11-9-23-7-5-20/h4-17,20H2,1-3H3
• InChI key: QGSFECNPSLZGGT-UHFFFAOYSA-N

설명

애플리케이션

This heterobifunctional, PEGylated crosslinker features an amino group at one end and t-butyl-protected carboxyl group at the other, which can be deprotected with acidic conditions. The hydrophillic PEG linker facilitates solubility in biological applications. Amino-PEG6-t-butyl ester can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC^® molecules) for targeted protein degradation.

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법적 정보

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

안전성 정보

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable