700116P

7-dehydrocholesterol-d7

7-dehydrocholesterol-d7, powder

• 동의어(들): 111110
• 실험식(Hill 표기법): C₂₇H₃₇D₇O
• CAS Number: 388622-58-0
• Molecular Weight: 391.68
• MDL number: MFCD22570234
• UNSPSC 코드: 41141804
• NACRES: NA.25

속성

• 분석: >99% (TLC)
• 양식: powder
• 포장: pkg of 1 × 1 mg (700116P-1mg)
• 제조업체/상표: Avanti Research^™ - A Croda Brand 700116P
• 배송 상태: dry ice
• 저장 온도: −70°C
• SMILES string: O[C@H]1CC[C@@]2([C@H]3CC[C@]4([C@@H](CC[C@@H]4[C@@H](CCCC(C([2H])([2H])[2H])(C([2H])([2H])[2H])[2H])C)C3=CC=C2C1)C)C
• InChI: 1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9-10,18-19,21,23-25,28H,6-8,11-17H2,1-5H3/t19-,21+,23-,24+,25+,26+,27-/m1/s1/i1D3,2D3,18D
• InChI key: UCTLRSWJYQTBFZ-UDEPUTHCSA-N

설명

일반 설명

7-dehydrocholesterol (7-DHC) is a cholesterol precursor and is localized in basal epidermal keratinocytes. 7DHC on photolysis in the presence of ultraviolet light B generates previtamin D3. The enzyme 7-dehydrocholesterol reductase (DHCR7) catalyzes the reduction of C(7-8) double bond of 7-DHC to cholesterol. 7-dehydrocholesterol-d7 is a deuterated derivative of 7-dehydrocholesterol.

애플리케이션

7-dehydrocholesterol-d7 has been used:

• as an internal standard: to spike Chlamydomonas CC-125 lipid extract for mass spectroscopy analysis
• in liquid chromatography–mass spectrometry (LC-MS) for cultured cells oxysterol analysis
• to treat and label SRD-1 cell (chinese hamster ovary (CHO) mutant cell-line) for gas chromatography/mass spectrometry (GC/MS) analysis

생화학적/생리학적 작용

7-Dehydrocholesterol (7-DHC) is used as a precursor for microbial vitamin D3 production. Impairment of 7-dehydrocholesterol reductase (DHCR7) functionality leads to 7-DHC accumulation and is implicated in Smith-Lemli-Opitz syndrome (SLOS).

포장

5 mL Amber Glass Screw Cap Vial (700116P-1mg)

법적 정보

Avanti Research is a trademark of Avanti Polar Lipids, LLC

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable