557502

Ro-20-1724

≥98% (TLC), solid, cAMP phosphodiesterase inhibitor, Calbiochem

• 동의어(들): Ro-20-1724, 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone
• 실험식(Hill 표기법): C₁₅H₂₂N₂O₃
• CAS Number: 29925-17-5
• Molecular Weight: 278.35
• MDL number: MFCD00077397
• UNSPSC 코드: 12352200
• NACRES: NA.77

속성

• Product Name: Ro-20-1724, A cell-permeable, selective inhibitor of cAMP-specific phosphodiesterase (PDE IV; IC₅₀ = 2 µM).
• Quality Level: 100
• 분석: ≥98% (TLC)
• 양식: solid
• 제조업체/상표: Calbiochem^®
• 저장 조건: OK to freeze
• 색상: white
• solubility: DMSO: 20%; ethanol: 4%
• 배송 상태: ambient
• 저장 온도: 10-30°C
• SMILES string: N1C(CNC1=O)Cc2cc(c(cc2)OC)OCCCC
• InChI: 1S/C15H22N2O3/c1-3-4-7-20-14-9-11(5-6-13(14)19-2)8-12-10-16-15(18)17-12/h5-6,9,12H,3-4,7-8,10H2,1-2H3,(H2,16,17,18)
• InChI key: PDMUULPVBYQBBK-UHFFFAOYSA-N

설명

일반 설명

A cell-permeable, selective inhibitor of cAMP-specific phosphodiesterase (PDE IV; IC₅₀ = 2 µM). Inhibits superoxide generation and arachidonic-induced platelet aggregation. Also inhibits fMLP-induced neutrophil adhesion to vascular endothelial cells.

Selective inhibitor of cAMP-specific phosphodiesterase (PDE IV, IC₅₀ = 2 µM). Inhibits superoxide generation and arachidonic-induced platelet aggregation. Also inhibits fMLP-induced neutrophil adhesion to vascular endothelial cells.

생화학적/생리학적 작용

Cell permeable: yes

Primary Target
PDE IV

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 2 µM against PDE IV

경고

Toxicity: Irritant (B)

기타 정보

Derian, C.K., et al. 1995. J. Immunol. 154, 308.
Rubin, L.L., et al. 1991. J. Cell Biol.115, 1725.
Lad, P.M., et al. 1985. Biochim. Biophys. Acta 846, 286.
Bergstrand, H., et al. 1977. Mol. Pharmacol.13, 38.

법적 정보

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable