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주요 문서

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C3912

8-(4-Chlorophenylthio)adenosine 3′,5′-cyclic monophosphate sodium salt

Name: 8-(4-Chlorophenylthio)adenosine 3′,5′-cyclic monophosphate sodium salt
Brand: SIGMA

≥97.0% (HPLC), powder

동의어(들):

pCPT-cAMP

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모든 사진(3)

About This Item

실험식(Hill 표기법):

C₁₆H₁₄ClN₅NaO₆PS

CAS Number:

93882-12-3

Molecular Weight:

493.79

EC Number:

299-413-9

MDL number:

MFCD00057683

UNSPSC 코드:

41106305

PubChem Substance ID:

24278024

NACRES:

NA.77

추천 제품

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Sigma-Aldrich

557502

Ro-20-1724

SYND214200

Synthware^™ vacuum jacketd Vigreux distillation head

Sigma-Aldrich

S9318

Sandoz 58-035

Sigma-Aldrich

P4333

Penicillin-Streptomycin

Sigma-Aldrich

A9501

Adenosine 3′,5′-cyclic monophosphate

Sigma-Aldrich

E3019

Esterase from porcine liver

BR25900

BRAND^® pipette controller micro-classic

Sigma-Aldrich

P2443

Pluronic^® F-127

Sigma-Aldrich

SML3072

8-pCPT-2′-O-Me-cAMP-AM

Sigma-Aldrich

D0627

N⁶,2′-O-Dibutyryladenosine 3′,5′-cyclic monophosphate sodium salt

Quality Level

200

분석

≥97.0% (HPLC)

양식

powder

색상

white

solubility

H₂O: 25 mg/mL

저장 온도

−20°C

SMILES string

[Na+].Nc1ncnc2n([C@@H]3O[C@@H]4COP([O-])(=O)O[C@H]4[C@H]3O)c(Sc5ccc(Cl)cc5)nc12

InChI

1S/C16H15ClN5O6PS.Na/c17-7-1-3-8(4-2-7)30-16-21-10-13(18)19-6-20-14(10)22(16)15-11(23)12-9(27-15)5-26-29(24,25)28-12;/h1-4,6,9,11-12,15,23H,5H2,(H,24,25)(H2,18,19,20);/q;+1/p-1/t9-,11-,12-,15-;/m1./s1

InChI key

YIJFVHMIFGLKQL-DNBRLMRSSA-M

유전자 정보

human ... PRKAR1A(5573), PRKAR1AP(5574), PRKAR1B(5575), PRKAR2A(5576), PRKAR2B(5577)

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애플리케이션

8-(4-Chlorophenylthio)adenosine 3′,5′-cyclic monophosphate sodium salt has been used:

to upregulate cellular cholesterol pump (adenosine triphosphate- (ATP-) binding cassette (ABC) transporter-1, ABCA-1)
in glucose production assay
to stimulate cystic fibrosis transmembrane conductance regulator (CFTR) channel in airway epithelia

생화학적/생리학적 작용

Membrane permeable cAMP analog. Used as a selective activator of cAMP dependent protein kinase (PKA). Inhibits cGMP-dependent phosphodiesterase and, at higher concentrations, inhibits cAMP-dependent phosphodiesterase. Inhibits phosphoinositide hydrolysis and secretion stimulated by n-formyl-Met-Leu-Phe but not platelet-activating factor in leukocytes. Renders HL-60 cells more resistant to NO-induced DNA damage.

특징 및 장점

This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.