추천 제품
Product Name
Aurintricarboxylic acid, practical grade, ≥85% (titration), powder
Grade
practical grade
분석
≥85% (titration)
양식
powder
기술
titration: suitable
색상
red to very dark red, and Red-Brown andBrown-Red
mp
300 °C (lit.)
solubility
1 M NH4OH: 10 mg/mL
응용 분야
diagnostic assay manufacturing
hematology
histology
저장 온도
room temp
SMILES string
OC(=O)c1cc(ccc1O)C(\c2ccc(O)c(c2)C(O)=O)=C3\C=CC(=O)C(=C3)C(O)=O
InChI
1S/C22H14O9/c23-16-4-1-10(7-13(16)20(26)27)19(11-2-5-17(24)14(8-11)21(28)29)12-3-6-18(25)15(9-12)22(30)31/h1-9,23-24H,(H,26,27)(H,28,29)(H,30,31)
InChI key
GIXWDMTZECRIJT-UHFFFAOYSA-N
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애플리케이션
- Aurintricarboxylic acid has been used to show its anticryptosporidial activity against Cryptosporidium parvum.
- It has been used as a test substance to identify inhibitors against coronavirus N7-MTases (guanine-N7-methyltransferase).
- It has been used as a ribonuclease inhibitor.
생화학적/생리학적 작용
Readily polymerizes in aqueous solution, forming a stable free radical that inhibits protein-nucleic acid interactions. It is a potent inhibitor of ribonuclease and topoisomerase II by preventing the binding of the nucleic acid to the enzyme. It stimulates tyrosine phosphorylation processes including the Jak2/STAT5 pathway in NB2 lymphoma cells, ErbB4 in neuroblastoma cells, and MAP kinases, Shc proteins, phosphatidylinositide 3-kinase and phospholipase Cγ in PC12 cells. Inhibits apoptosis. It prevents down-regulation of Ca2+ -impermeable GluR2 receptors and inhibits calpain, a Ca2+ -activated protease that is activated during apoptosis.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
개인 보호 장비
dust mask type N95 (US), Eyeshields, Gloves
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