H2380

6-Hydroxy-DL-DOPA

≥98% (HPLC), powder, APE1 inhibitor

• 동의어(들): 2,4,5-Trihydroxy-DL-phenylalanine, 2,5-Dihydroxy-DL-tyrosine
• 실험식(Hill 표기법): C₉H₁₁NO₅
• CAS Number: 21373-30-8
• Molecular Weight: 213.19
• Beilstein: 2860065
• MDL number: MFCD00004272
• UNSPSC 코드: 12352200
• PubChem Substance ID: 24278464
• NACRES: NA.32

속성

• Product Name: 6-Hydroxy-DL-DOPA, ≥98% (HPLC), powder
• Quality Level: 200
• 분석: ≥98% (HPLC)
• 양식: powder
• 색상: off-white
• solubility: H₂O: 3 mg/mL; 1 M HCl: 50 mg/mL (Solutions should be freshly prepared and protected from exposure to light.)
• 저장 온도: −20°C
• SMILES string: NC(Cc1cc(O)c(O)cc1O)C(O)=O
• InChI: 1S/C9H11NO5/c10-5(9(14)15)1-4-2-7(12)8(13)3-6(4)11/h2-3,5,11-13H,1,10H2,(H,14,15)
• InChI key: YLKRUSPZOTYMAT-UHFFFAOYSA-N

설명

일반 설명

Dissolve in oxygen-free boiled water containing 0.1% sodium metabisulfite or other antioxidant. Solutions should be freshly prepared and protected from exposure to light.

생화학적/생리학적 작용

6-Hydroxy-DL-DOPA is an inhibitor of APE1 (apurinic/apyrimidinic endonuclease) repair-function activity. APE1 is a nuclease crucial for DNA base excision repair pathway. 6-Hydroxy-DL-DOPA also blocks RAD52 (DNA repair protein) single-stranded DNA binding domain.

Precursor 6-hydroxydopamine.

Precursor of the catecholaminergic neurotoxin, 6-hydroxydopamine; converted to 6-hydroxydopamine by L-aromatic amino acid decarboxylase.

포장

Bottomless glass bottle. Contents are inside inserted fused cone.

주의사항

Hygroscopic; photosensitive

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Gloves, type N95 (US)