A265

ARL 67156 trisodium salt hydrate

≥98% (HPLC), solid, ecto-ATPase inhibitor

• 동의어(들): 6-N,N-Diethyl-β-γ-dibromomethylene-D-adenosine-5′-triphosphate trisodium salt hydrate, FPL 67156
• 실험식(Hill 표기법): C₁₅H₂₁Br₂N₅Na₃O₁₂P₃ · xH₂O
• CAS Number: 160928-38-1
• Molecular Weight: 785.05 (anhydrous basis)
• MDL number: MFCD12910436
• UNSPSC 코드: 12352200
• PubChem Substance ID: 24278252
• NACRES: NA.77

속성

• Product Name: ARL 67156 trisodium salt hydrate, ≥98% (HPLC), solid
• Quality Level: 100
• 분석: ≥98% (HPLC)
• 양식: solid
• 색상: white to off-white
• solubility: H₂O: >20 mg/mL; DMSO: insoluble
• 저장 온도: −20°C
• SMILES string: O.[Na+].[Na+].[Na+].CCN(CC)c1ncnc2n(cnc12)[C@@H]3O[C@H](COP(O)(=O)OP([O-])(=O)C(Br)(Br)P([O-])([O-])=O)[C@@H](O)[C@H]3O
• InChI: 1S/C15H24Br2N5O12P3.3Na.H2O/c1-3-21(4-2)12-9-13(19-6-18-12)22(7-20-9)14-11(24)10(23)8(33-14)5-32-37(30,31)34-36(28,29)15(16,17)35(25,26)27;;;;/h6-8,10-11,14,23-24H,3-5H2,1-2H3,(H,28,29)(H,30,31)(H2,25,26,27);;;;1H2/q;3*+1;/p-3/t8-,10-,11-,14-;;;;/m1..../s1
• InChI key: UWMONIJVKGTUGE-OPKBHZIBSA-K
• 유전자 정보: human ... ENTPD2(954)

설명

일반 설명

ARL 67156, a nucleotide/ATP analog is a competitive inhibitor of CD39. This ecto-ATPase inhibitor is presumed to be metabolically stable in biological studies due to its β, γ-dibromomethylene bridge.

ARL-67156 preferentially inhibits the degradation of ADP compared to the degradation of ATP in the murine colon. It is commonly employed to inhibit ATP hydrolysis in tissue preparations.

애플리케이션

ARL 67156 trisodium salt hydrate has been used:

• to prevent ATP degradation during cerebrospinal fluid extraction
• as an ATPase inhibitor in ATP quantification assay for preventing ATP degradation in cytoplasm and mitochondrion
• as an ecto-ATPase inhibitor to treat cancer cells for ATP release assay

생화학적/생리학적 작용

ecto-ATPase inhibitor; prevents metabolism of P₂ purinoceptor agonists.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3