C1494

Carmofur

≥98% (HPLC), powder

• 동의어(들): 1-Hexylcarbamoyl-5-fluorouracil, HCFU
• 실험식(Hill 표기법): C₁₁H₁₆FN₃O₃
• CAS Number: 61422-45-5
• Molecular Weight: 257.26
• MDL number: MFCD00866284
• UNSPSC 코드: 12352200
• PubChem Substance ID: 329774890
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: ≥98% (HPLC)
• 양식: powder
• 색상: white to off-white
• solubility: DMSO: >15 mg/mL
• 저장 온도: 2-8°C
• SMILES string: CCCCCCNC(=O)N1C=C(F)C(=O)NC1=O
• InChI: 1S/C11H16FN3O3/c1-2-3-4-5-6-13-10(17)15-7-8(12)9(16)14-11(15)18/h7H,2-6H2,1H3,(H,13,17)(H,14,16,18)
• InChI key: AOCCBINRVIKJHY-UHFFFAOYSA-N

설명

애플리케이션

Carmofur has been used as an inhibitor of acid ceramidase to study its effects on glucosylsphingosine (GlcSph) production in human embryonic kidney 293T (HEK293T) cells. It has also been used as an inhibitor of acid ceramidase to study its effects on acid‐mediated hydrolysis of ceramide which kicks-in consumption and the generation of sphingosine .

생화학적/생리학적 작용

Carmofur acts as an inhibitor of fatty acid amide hydrolase (FAAH), N-acylethanolamine acid amidase (NAAA) and acid ceramidase (ASAH1). Carmofur has a therapeutic activity against colorectal and cervical cancer. It can inhibit the severe acute respiratory syndrome (SARS)-CoV-2 main protease (M^pro) in vitro.

Carmofur is a derivative of fluorouracil, an antimetabolite used as an antineoplastic agent.

Carmofur is an antineoplastic agent and a flurorouracil analog.

안전성 정보

• 픽토그램: GHS06,GHS08
• 신호어: Danger
• 유해 및 위험 성명서: H301,H361
• 예방조치 성명서: P201 - P301 + P310 + P330
• Hazard Classifications: Acute Tox. 3 Oral - Repr. 2
• Storage Class Code: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable