C271

CX546

≥98% (HPLC), solid

• 동의어(들): 1-(1,4-Benzodioxan-6-ylcarbonyl)piperidine
• 실험식(Hill 표기법): C₁₄H₁₇NO₃
• CAS Number: 215923-54-9
• Molecular Weight: 247.29
• MDL number: MFCD01860868
• UNSPSC 코드: 12352200
• PubChem Substance ID: 24277960
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: ≥98% (HPLC)
• 양식: solid
• 저장 조건: protect from light
• 색상: white to off-white
• solubility: DMSO: ≥10 mg/mL
• 저장 온도: 2-8°C
• SMILES string: O=C(N1CCCCC1)c2ccc3OCCOc3c2
• InChI: 1S/C14H17NO3/c16-14(15-6-2-1-3-7-15)11-4-5-12-13(10-11)18-9-8-17-12/h4-5,10H,1-3,6-9H2
• InChI key: LJUNPHMOGNFFOS-UHFFFAOYSA-N
• 유전자 정보: human ... GRIA1(2890), GRIA2(2891), GRIA3(2892), GRIA4(2893)

설명

일반 설명

CX546, a benzoylpiperidine derivative ampakine is an analog of CX516.

애플리케이션

CX546 has been used as positive allosteric modulator for the glutamatergic receptor α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) in mice.

생화학적/생리학적 작용

CX546 has antipsychotic functionality and has the potential to treat schizophrenia. It improves the defects associated with the prepulse inhibition (PPI) and latent inhibition (LI) in mice lacking metabotropic glutamate receptor type 5 (mGluR5). Additionally, CX546 potentiates synaptic plasticity, elicits neuroprotection and promotes the neurotrophin expression.

Positive AMPA glutamate receptor modulator.

주의사항

Photosensitive

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Gloves, type N95 (US)