E7138

Ethosuximide

• 동의어(들): 2-Ethyl-2-methylsuccinimide
• 실험식(Hill 표기법): C₇H₁₁NO₂
• CAS Number: 77-67-8
• Molecular Weight: 141.17
• EC Number: 201-048-7
• MDL number: MFCD00072123
• UNSPSC 코드: 12352111
• PubChem Substance ID: 24278423
• NACRES: NA.77

속성

• Quality Level: 100
• solubility: ethanol: 100 mg/mL
• SMILES string: O=C1NC(CC1(C)CC)=O
• InChI: 1S/C7H11NO2/c1-3-7(2)4-5(9)8-6(7)10/h3-4H2,1-2H3,(H,8,9,10)
• InChI key: HAPOVYFOVVWLRS-UHFFFAOYSA-N
• 유전자 정보: human ... CACNA1G(8913), CACNA1H(8912), CACNA1I(8911)

설명

애플리케이션

Ethosuximide has been used:

• to confirm its effect on spike wave discharges (SWD) in rats
• to examine its effects on spontaneous locomotion and anxiety-related thigmotaxis behaviours in zebrafish larvae of wild type
• as a model drug for the treatment of epilepsy in vivo(4)

생화학적/생리학적 작용

Ethosuximide is an anticonvulsant drug and an antagonist for T-type calcium channel. It is known to prevent spike wave discharges, characterized in absence seizures.

특징 및 장점

This compound is featured on the Calcium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

안전성 정보

• 픽토그램: GHS07
• 신호어: Warning
• 유해 및 위험 성명서: H302
• 예방조치 성명서: P264 - P270 - P301 + P312 - P501
• Hazard Classifications: Acute Tox. 4 Oral
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: dust mask type N95 (US), Eyeshields, Gloves