I2526

Insulin-like Growth Factor-II human

≥98% (SDS-PAGE and HPLC), recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture

• 동의어(들): IGF-II
• MDL number: MFCD00241895
• UNSPSC 코드: 12352202
• NACRES: NA.77

속성

• Product Name: Insulin-like Growth Factor-II human, IGF-II, recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture
• 생물학적 소스: human
• Quality Level: 200
• 재조합: expressed in E. coli
• 분석: ≥98% (SDS-PAGE and HPLC)
• 양식: lyophilized powder
• 효능: ≤2.0 ng/mL ED₅₀
• 품질: endotoxin tested
• 분자량: 7.5 kDa
• 포장: pkg of 5X50 μg; pkg of 50 μg
• 기술: cell culture | mammalian: suitable
• 불순물: ≤0.1 EU/μg
• UniProt 수납 번호: P01344
• 저장 온도: −20°C
• 유전자 정보: human ... IGF2(3481)

설명

생화학적/생리학적 작용

IGF-II, also known as multiplication stimulating activity (MSA), shows virtually identical bioactivities as IGF-I. IGF-II binds to the IGF-II receptor, IGF-I receptor, and weakly to the insulin receptor (IR). All IGF-II bioactivities in adult tissues are generally attributed to its interaction with IGF-I receptor. However, during embryogenesis the roles of both IGF-II receptor and IR may be significant in promoting normal growth.

Insulin-like growth factor II (IGF-II) also known as multiplication stimulating activity (MSA), shows virtually identical bioactivities as IGF-I. Expression of IGF-II is highest in fetal tissues, where it is believed to play a major role in overall growth and development. After birth IGF-II expression decreases to much lower levels in a variety of tissues. IGF-II is produced also in several tumors. IGF-II binds to IGF-II receptor (IGF-IIR), to IGF-IR and weakly to the insulin receptor (IR). All IGF-II bioactivities in adult tissues are generally attributed to its interaction with IGF-IR. However, during embryogenesis the roles of both IGF-IIR and IR may be significant in promoting normal growth.

물리적 형태

Lyophilized from a 0.2 μm filtered solution with no additives.

분석 메모

The biological activity is measured by a cell proliferation assay using mouse FDC-P1

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Gloves, type N95 (US)