J4144

Jo-1 human

recombinant, expressed in E. coli, solution

• MDL number: MFCD03457272
• UNSPSC 코드: 12352204
• NACRES: NA.83

속성

• 재조합: expressed in E. coli
• Quality Level: 200
• 양식: solution
• 분자량: 55 kDa by SDS-PAGE
• UniProt 수납 번호: P12081
• 배송 상태: dry ice
• 저장 온도: −70°C
• 유전자 정보: human ... HARS(3035)

설명

일반 설명

Jo-1, or histidyl-transfer ribonucleic acid synthetase, is a homodimeric enzyme that catalyzes the coupling of histidine to its specific transfer RNA (tRNA), prior to transport of histidine to the ribosome, and subsequent incorporation of histidine into polypeptide chains. Jo-1 has been associated with various autoimmune disorders, such as polymyositis and dermatomyositis, and T-cell mediated autoimmunity.

생화학적/생리학적 작용

The anti-Jo-1 antibody has been associated with an increased frequency of interstitial pulmonary disease in polymyositis/dermatomyositis patients.

Used in the immunoassay for antibodies to Jo-1.

물리적 형태

Solution in 6 M urea, 500 mM sodium chloride, 10 mM Tris HCl buffer, pH 8.0.

안전성 정보

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 1
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable