L7757

Lidocaine

≥98% (GC), powder, neuroprotective agent

• 동의어(들): 2-Diethylamino-N-(2,6-dimethylphenyl)acetamide, Lignocaine, Xylocaine
• 실험식(Hill 표기법): C₁₄H₂₂N₂O
• CAS Number: 137-58-6
• Molecular Weight: 234.34
• EC Number: 205-302-8
• MDL number: MFCD00026733
• UNSPSC 코드: 12352200
• PubChem Substance ID: 24896480
• NACRES: NA.77

속성

• Product Name: Lidocaine, powder
• 양식: powder
• Quality Level: 100
• SMILES string: CCN(CC)CC(=O)Nc1c(C)cccc1C
• InChI: 1S/C14H22N2O/c1-5-16(6-2)10-13(17)15-14-11(3)8-7-9-12(14)4/h7-9H,5-6,10H2,1-4H3,(H,15,17)
• InChI key: NNJVILVZKWQKPM-UHFFFAOYSA-N
• 유전자 정보: human ... CYP1A2(1544), SCN10A(6336), SCN11A(11280), SCN1A(6323), SCN2A(6326), SCN3A(6328), SCN4A(6329), SCN5A(6331), SCN7A(6332), SCN8A(6334), SCN9A(6335) ; rat ... Scnn1a(25122)

설명

일반 설명

Lidocaine is a local anesthetic and an effective antiarrhythmia agent. It occurs as solutions of crystalline colorless solid for injections, that has a short half-life within plasma.

애플리케이션

Lidocaine may be used for drug testing and for voltage clamp experiments.

생화학적/생리학적 작용

Lidocaine, a neuroprotective agent, mediates blockage of sodium (Na⁺) channels. It prevents the influx of sodium ions leading to depolarization of sodium channels and metabolically inactivated in liver. Lidocaine has positive effect on cerebral ischemia. It is also used in the treatment of ventricular tachycardia. Lidocaine is an efficient anesthetic agent in ophthalmic surgeries as it is highly potent and has good tissue penetrability.

Na⁺ channel blocker; class IB antiarrhythmic that is rapidly absorbed after parenteral administration.

Na⁺ channel blocker; class IB antiarrhythmic.

안전성 정보

• 픽토그램: GHS07
• 신호어: Warning
• 유해 및 위험 성명서: H302
• 예방조치 성명서: P264 - P270 - P301 + P312 - P501
• Hazard Classifications: Acute Tox. 4 Oral
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: dust mask type N95 (US), Eyeshields, Faceshields, Gloves