M2727

Mexiletine hydrochloride

≥98% (GC), powder, sodium channel blocker

• 동의어(들): 1-(2,6-Dimethylphenoxy)-2-propanamine hydrochloride, 1-(2,6-Xylyloxy)-2-aminopropane hydrochloride
• 실험식(Hill 표기법): C₁₁H₁₇NO · HCl
• CAS Number: 5370-01-4
• Molecular Weight: 215.72
• EC Number: 250-825-7
• MDL number: MFCD00216024
• UNSPSC 코드: 12352200
• PubChem Substance ID: 24278542
• NACRES: NA.77

속성

• Product Name: Mexiletine hydrochloride, powder
• 분석: ≥98% (GC)
• Quality Level: 200
• 양식: powder
• 색상: white to off-white
• solubility: methanol: 50 mg/mL
• 주관자: Boehringer Ingelheim
• 저장 온도: 2-8°C
• SMILES string: Cl[H].CC(N)COc1c(C)cccc1C
• InChI: 1S/C11H17NO.ClH/c1-8-5-4-6-9(2)11(8)13-7-10(3)12;/h4-6,10H,7,12H2,1-3H3;1H
• InChI key: NFEIBWMZVIVJLQ-UHFFFAOYSA-N
• 유전자 정보: human ... SCN10A(6336), SCN11A(11280), SCN1A(6323), SCN2A(6326), SCN3A(6328), SCN4A(6329), SCN5A(6331), SCN7A(6332), SCN8A(6334), SCN9A(6335)

설명

일반 설명

Mexiletine is a class I B antiarrhythmic and an analog of lidocaine. It has shelf life of 10-12 hours and is metabolized in liver and eliminated post reduction, oxidation deamination or conjugation.

애플리케이션

Mexiletine hydrochloride has been used as a sodium channel blocker:

• expressed in chinese hamster ovary cells
• in human embryonic kidney (HEK) cells for whole cell patch-clamp studies
• electrophysiology studies in HEK cells expressing Nav1.7 protein

생화학적/생리학적 작용

Mexiletine is a potent sodium channel blocker. It is a cardiac antiarrhythmic and is used as an adjuvant in headache and neuropathic pain Mexiletine is used for treating myotonia in sodium channelopathies and reduces the cardiac action potential depolarization but shows no impact on atrial refractoriness. Its inhibitory effect on sodium channels is effective in treating potassium aggravated myotonia.

특징 및 장점

This compound was developed by Boehringer Ingelheim. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

안전성 정보

• 픽토그램: GHS07
• 신호어: Warning
• 유해 및 위험 성명서: H302
• 예방조치 성명서: P264 - P270 - P301 + P312 - P501
• Hazard Classifications: Acute Tox. 4 Oral
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable