N1408

Nerve Growth Factor β Human

>97% (SDS-PAGE), recombinant, expressed in NSO cells, lyophilized powder, suitable for cell culture

• 동의어(들): HSAN5, NGF-β human, NGFB, hNGFβ
• MDL number: MFCD00164982
• UNSPSC 코드: 12352202
• NACRES: NA.77

속성

• Product Name: NGF-β human, from human, recombinant, expressed in NSO cells, lyophilized powder, suitable for cell culture
• 생물학적 소스: human
• Quality Level: 200
• 재조합: expressed in NSO cells
• 분석: >97% (SDS-PAGE)
• 양식: lyophilized powder
• 효능: 0.15-3.0 ng/mL ED₅₀/EC₅₀
• 품질: endotoxin tested
• 포장: pkg of 5X0.1 mg; pkg of 0.1 mg
• 기술: cell culture | mammalian: suitable
• 불순물: <1 EU/μg
• solubility: water: soluble 0.1 g/L at 20 °C
• UniProt 수납 번호: P01138
• 저장 온도: −20°C
• 유전자 정보: human ... NGF(4803)

설명

일반 설명

The nerve growth factor β (NGFB) gene is mapped to human chromosome 1p13.2.

애플리케이션

NGF-β human has been used:

• in protein pin arrays
• to induce U87-MG (glioblastoma cell line) cell proliferation
• in drug release kinetics

생화학적/생리학적 작용

Nerve growth factor β (NGFB) acts as a key mediator in neuronal and non-neuronal development, differentiation, and survival. Polymorphism of NGFB gene leads to hereditary sensory and autonomic neuropathies. Charcot arthropathy and thermal insensitivity are few of the related symptoms. NGFβ is known to promote cancer cell proliferation and metastasis, also mediates angiogenesis. It facilitates the development of various cancer including, oral, breast, lungs, pancreatic and prostate cancers. Elevated expression of NGFβ contributes to progression of human cholangiocarcinoma. In animal models, NGFβ is observed to prevent cholinergic neuron loss and enhances memory. NGF-β promotes the survival and cholinergic phenotype of basal forebrain cholinergic neurons and stimulates neurite outgrowth of embryonic trigeminal motor neurons in vitro.

물리적 형태

Lyophilized from 0.2% acetic acid containing 5 mg bovine serum albumin.

분석 메모

The biological activity is measured in a cell proliferation assay using a factor-dependent human erythroleukemic cell line, TF-1.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Gloves, type N95 (US)