O9389

Oltipraz

≥98% (HPLC), powder

• 동의어(들): 4-Methyl-5-(2-pyrazinyl)-1,2-dithiole-3-thione, BRN 0978110, CCRIS 4048, NSC 347901, RP 35972
• 실험식(Hill 표기법): C₈H₆N₂S₃
• CAS Number: 64224-21-1
• Molecular Weight: 226.34
• EC Number: 264-736-6
• MDL number: MFCD00868499
• UNSPSC 코드: 12352200
• PubChem Substance ID: 329818939
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: ≥98% (HPLC)
• 양식: powder
• 저장 조건: protect from light
• 색상: red
• solubility: DMSO: >20 mg/mL
• 저장 온도: 2-8°C
• SMILES string: CC1=C(SSC1=S)c2cnccn2
• InChI: 1S/C8H6N2S3/c1-5-7(12-13-8(5)11)6-4-9-2-3-10-6/h2-4H,1H3
• InChI key: CKNAQFVBEHDJQV-UHFFFAOYSA-N

설명

일반 설명

Oltipraz, a dithiol derivative, is a member of dithiolethiones class of organosulfur compounds. It has anti-tumor, antioxidative, anti- inflammatory and radioprotective properties. It provides protection from numerous carcinogens. Oltipraz functions as a schistosomicide.

생화학적/생리학적 작용

Oltipraz is an activator of Nrf2.

Oltipraz is an activator of Nrf2. Nrf2 (NF-E2-related factor 2) is a transcription factor that binds to antioxidant response elements (AREs) and activates these genes. Oltipraz activates Nrf2 and subsequently elevates expression of the detoxification genes encoding anti-oxidant and multidrug resistance-associated proteins to mediate its chemopreventive efficacy.

안전성 정보

• 픽토그램: GHS07
• 신호어: Warning
• 유해 및 위험 성명서: H315,H319,H335
• 예방조치 성명서: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• 표적 기관: Respiratory system
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: dust mask type N95 (US), Eyeshields, Gloves