P0778

Pindolol

≥98% (TLC), powder

• 동의어(들): 1-(1H-Indol-4-yloxy)-3-(isopropylamino)-2-propanol, 1-(1H-Indol-4-yloxy)-3-[(1-methylethyl)amino]-2-propanol
• 실험식(Hill 표기법): C₁₄H₂₀N₂O₂
• CAS Number: 13523-86-9
• Molecular Weight: 248.32
• EC Number: 236-867-9
• MDL number: MFCD00010530
• UNSPSC 코드: 12352200
• PubChem Substance ID: 24277795
• NACRES: NA.77

속성

• Quality Level: 200
• 분석: ≥98% (TLC)
• 양식: powder
• 색상: white to off-white
• mp: 167-171 °C (lit.)
• solubility: 0.1 M NaOH: 0.2 mg/mL; 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 0.2 mg/mL; 0.1 M HCl: 20 mg/mL; acetic acid: 50 mg/mL; H₂O: insoluble
• 주관자: Novartis
• 저장 온도: 2-8°C
• SMILES string: CC(C)NCC(O)COc1cccc2[nH]ccc12
• InChI: 1S/C14H20N2O2/c1-10(2)16-8-11(17)9-18-14-5-3-4-13-12(14)6-7-15-13/h3-7,10-11,15-17H,8-9H2,1-2H3
• InChI key: JZQKKSLKJUAGIC-UHFFFAOYSA-N
• 유전자 정보: human ... ADRB1(153), ADRB2(154), HTR1A(3350)

설명

애플리케이션

Pindolol has been used in intestinal transport and metabolism assays and cassette mix preparation.

생화학적/생리학적 작용

β1-adrenoceptor antagonist; putative 5-HT1A serotonin receptor agonist; vasodilator. Pindolol is a non-cardioselective beta-adrenergic blocking agent. It possesses intrinsic sympathomimetic activity.

β₁-adrenoceptor antagonist; putative 5-HT_1A serotonin receptor agonist; vasodilator.

특징 및 장점

Shelf-life of the powder is at least five years.

This compound is a featured product for ADME Tox and Neuroscience research. Discover more featured ADME Tox and Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the β-Adrenoceptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

안전성 정보

• 픽토그램: GHS07
• 신호어: Warning
• 유해 및 위험 성명서: H302,H315,H319,H335
• 예방조치 성명서: P261 - P264 - P270 - P301 + P312 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• 표적 기관: Respiratory system
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• 개인 보호 장비: dust mask type N95 (US), Eyeshields, Gloves